Evaluation of Acute and Repeated Dose Toxicity of the Polyherbal Formulation Linkus Syrup in Experimental Animals

January 2014 in “ Chinese medicine ”

Ahmad Nawaz, Saira Bano, Zeeshan Sheikh, Khan Usmanghani, Iqbal Ahmad, Syed Faisal Zaidi, Aqib Zahoor, Irshad Ahmad

Linkus syrup polyherbal formulation ALP creatinine protein levels

TLDR Linkus cough syrup is effective and safe with no side effects or toxicity in rats.

The study evaluated the acute and repeated dose toxicity of Linkus syrup, a polyherbal formulation, in Wistar albino rats. It found no mortality or significant adverse effects at doses up to 5 g/kg. Repeated doses of 20, 500, and 1000 mg/kg did not significantly alter most blood and urine parameters, though some changes in ALP, creatinine, and protein levels were noted. The syrup effectively reduced cough reflexes at 300 mg/kg without observed toxicity. Overall, Linkus syrup was deemed safe and effective for treating cough in the tested animal model.

View this study on scirp.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 282 results

community My baby is balding! (Norwood 7)

in Satire 1171 upvotes 9 months ago

The conversation is a satirical discussion about a baby with hair loss using adult hair loss treatments like finasteride, minoxidil, and ketoconazole, as well as dermarolling, scalp massages, and plans for PRP sessions. Suggestions include various other treatments and humorous advice, reflecting the satire of the situation.

community Male pattern baldness, and mental health

in Finasteride/Dutasteride 323 upvotes 8 months ago

A 48-year-old man has been using minoxidil for 15 years and considered finasteride but stopped due to potential side effects. He is concerned about his mental health and the impact of hair loss on self-image, and he encourages support among men experiencing hair loss.

community Links tressless

40 upvotes 6 years ago

The conversation is about hair loss treatments, including dermarolling, Minoxidil, Finasteride, and RU58841. Users discuss their experiences, side effects, and application methods for these treatments.

community A repository of links to current scientific research and findings into the nature of and relating to side-effects for Finasteride/Dutasteride/5a-reductase inhibitors.

in Finasteride 17 upvotes 5 years ago

Finasteride and dutasteride, used for hair loss, can cause sexual dysfunction, depression, and suicidal thoughts, with some effects persisting after stopping. The post stresses the importance of being aware of these risks.

community Finasteride/dutasteride/etcetera. Clinical opinions of 1 GP and 1 leading urologist + links to reliable studies.

in Finasteride 9 upvotes 5 years ago

Finasteride is effective for treating male pattern baldness (MPB) with minimal side effects, and topical finasteride is similarly effective. Dutasteride is also effective but less understood, and Minoxidil is less effective than Finasteride.

community could this be a reason for my hair loss

in Chat 13 upvotes 11 months ago

The post discusses potential links between low vitamin D levels and hair loss, and how correcting this might impact the effectiveness of Minoxidil and Finasteride treatments. The responses vary, with some suggesting that vitamin D deficiency would cause overall scalp hair loss, while others believe it would first affect the most sensitive areas.

Similar Research

5 / 1000+ results

research Diseases of the Skin: Treatment of Scalp Disorders

6 citations, February 1974 in “The BMJ”

The document concludes that scalp disorders can be treated with hair washing, specific shampoos, medications, and sometimes surgery or hair transplants, but hereditary baldness is untreatable.

Effect of High-Fructose Diet on the Renal Cortex of Adult Male Albino Rats

research Antiglycants

January 2017 in “Clinical approaches and procedures in cosmetic dermatology”

Anti-glycation treatments might slow skin aging, but more research is needed.