Cepharanthine Inhibits Enterovirus Entry by Endolysosomal Deacidification and Exhibits Protective Activity In Vivo

    Ta-Chou Weng, Bang-Yan Hsu, Szu‐Hao Kung
    Studysummary This study found that cepharanthine may be a promising treatment for enterovirus infections, as it offered full protection to mice against lethal EV71 challenges and reduced viral titers and pathology.
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    Research cited in this study 5

    1. Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways Frontiers in Microbiology · 2021
    2. Evaluating Cepharanthine Analogues as Natural Drugs Against SARS-CoV-2 FEBS Open Bio · 2021
    3. Comparison of Viral RNA–Host Protein Interactomes Across Pathogenic RNA Viruses Informs Rapid Antiviral Drug Discovery for SARS-CoV-2 Cell Research · 2021
    4. Cepharanthine: A Review of the Antiviral Potential of a Japanese-Approved Alopecia Drug in COVID-19 Pharmacological Reports · 2020
    5. Cepharanthine: An Update of Its Mode of Action, Pharmacological Properties, and Medical Applications Phytomedicine · 2019