Reduced Plakoglobin Increases the Risk of Sodium Current Defects and Atrial Conduction Abnormalities in Response to Androgenic Anabolic Steroid Abuse

    February 2024 in “ The Journal of Physiology ”
    Laura C. Sommerfeld, Andrew P. Holmes, Ting Yu, Christopher O’Shea, Deirdre M. Kavanagh, Jeremy A. Pike, Tom Wright, Fahima Syeda, Areej Aljehani, Tania Kew, Victor Roth Cardoso, S. Nashitha Kabir, Claire Hepburn, Priyanka Rajeev Menon, Sophie Broadway‐Stringer, Molly O’Reilly, Anika Witten, Lisa Fortmueller, Susanne Lutz, Alexandra Kulle, Georgios V. Gkoutos, Davor Pavlović, Wiebke Arlt, Gareth G. Lavery, Richard P. Steeds, Katja Gehmlich, Monika Stoll, Paulus Kirchhof, Larissa Fabritz
    Studysummary This study suggests that male sex and androgenic steroid use increase the risk of atrial arrhythmias in individuals with arrhythmogenic right ventricular cardiomyopathy, especially those with desmosomal gene mutations.
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