Targeting Receptor–Regulator Interactions

The document summarizes several studies on cancer and dermal disorders. One study found that a peptidomimetic could disrupt the interaction between the androgen receptor (AR) and the co-regulator protein PELP1, inhibiting AR nuclear translocation and androgen-induced proliferation, and reducing tumor growth in a mouse model of prostate cancer. Another study identified a secreted variant of the tumor suppressor PTEN, called PTEN-long, which could enter cells, antagonize PI3K signaling, and reduce tumor growth in mice, suggesting potential therapeutic benefits. A third study developed a thermodynamic sensor assay using the HSP90 chaperone to profile the specificity of 30 kinase inhibitors against over 300 kinases in living cells, identifying new targets for existing drugs. Lastly, a study on dermal disorders showed that fibroblast growth factor 9 (FGF9) is key for hair follicle regeneration after skin wounding in mice, and its overexpression increased neogenic hair follicles, indicating that FGF9 might be a target for inducing hair follicle regeneration in humans.