Hyperadrenocorticism Associated With Sex Steroid Excess

February 2007 in “ Clinical techniques in small animal practice ”

Deborah S. Greco

hyperadrenocorticism sex steroid excess trunkal hair loss perianal adenomas serum alkaline phosphatase serum alanine transferase medical treatment surgical treatment radiation treatment hair loss hormone imbalance liver enzymes

Studysummary This review discusses the etiology and clinical findings of atypical hyperadrenocorticism in dogs due to sex steroid imbalance and explores various treatment options, but reports no new results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document from 2007 discusses the diagnosis of sex steroid excess or hyperadrenocorticism in dogs, which can be difficult due to its varied manifestations that differ from standard hyperadrenocorticism. Unlike typical cases, dogs with sex steroid imbalance often do not show signs of polydipsia and polyuria but may present with trunkal hair loss, particularly in certain breeds like miniature poodles. Additionally, reproductive system involvement is common, with neutered male or female dogs developing perianal adenomas. Laboratory findings frequently indicate elevated serum alkaline phosphatase and serum alanine transferase levels. The article reviews the causes, typical characteristics, clinical signs, and lab findings of atypical hyperadrenocorticism due to sex steroid imbalance and discusses medical, surgical, and radiation treatment options.

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