This study found that a combination of betulin and cytostatic Namitecan had a statistically significant synergistic effect on solid Ehrlich adenocarcinoma tumors in NMRI mice, and suggests a promising method for administering betulin in in vivo experiments despite its water insolubility.
March 2024 in “International journal of pharmaceutical chemistry and analysis (Print)” In this study, albino wistar rats with testosterone-induced alopecia showed improved hair growth when treated with betulin, evidenced by increased hair length and decreased cholesterol and testosterone levels.
January 2026 in “In Silico Research in Biomedicine” This study used computational methods to explore the potential of betulinic acid from Ziziphus spina-christi in treating alopecia, suggesting its possible protective effects on hair follicles by enhancing genomic stability and reducing oxidative damage, meriting further experimental validation.
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July 2024 in “Journal of Investigative Dermatology” VYN201 shows promise as a safe and effective treatment for non-segmental vitiligo.
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June 2024 in “Archives of Dermatological Research” In this pilot study, researchers found that betulin did not conclusively inhibit hair loss or promote regrowth in patients with hypothyroidism when compared to placebo.