Engineered Hair Follicle Mesenchymal Stem Cells Overexpressing Controlled-Release Insulin Reverse Hyperglycemia in Mice with Type 1 Diabetes

May 2014 in “ Cell transplantation ”

Chunling Wu, Feilin Liu, Pengdong Li, Guifang Zhao, Shaowei Lan, Wenyue Jiang, Xiangyi Meng, Lixing Tian, Gang Li, Yulin Li, Jin Yu Liu

hair follicle mesenchymal stem cells HF-MSCs insulin rapamycin multipotency cell apoptosis

Studysummary This study demonstrated that genetically engineered stem cells from human hair follicles can reverse hyperglycemia and reduce mortality in mice with type 1 diabetes by overexpressing the human insulin gene.

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Research cited in this study

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research Maintenance of High Proliferation and Multipotent Potential of Human Hair Follicle-Derived Mesenchymal Stem Cells by Growth Factors

56 citations , February 2013 in “International Journal of Molecular Medicine”

This study found that human hair follicle-derived mesenchymal stem cells maintained their proliferation and differentiation potential when cultured with acidic fibroblast growth factor, basic fibroblast growth factor, or epidermal growth factor.

research Cultured Cells From the Adult Human Hair Follicle Dermis Can Be Directed Toward Adipogenic and Osteogenic Differentiation

38 citations , April 2005 in “Journal of Investigative Dermatology”

Human hair follicle cells can become fat and bone cells, useful for therapy.