Matriptase-2, A Novel Suppressor of Hepcidin

November 2009 in “ Blood ”

Clara Camaschella, Antonella Nai, Alessia Pagani, Laura Silvestri

matriptase-2 TMPRSS6 gene hepcidin iron metabolism iron deficiency erythropoietic expansion iron-refractory iron-deficiency anemia IRIDA hemojuvelin bone morphogenetic protein pathway BMP pathway iron deficiency anemia hair loss

Studysummary This study found that mutations in the TMPRSS6 gene affect the ability of matriptase-2 to inhibit hepcidin, which may impact the molecular pathogenesis of iron-refractory iron-deficiency anemia.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer ·

View this study on ashpublications.org →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

research The Mask Mutation Identifies TMPRSS6 as an Essential Suppressor of Hepcidin Gene Expression, Required for Normal Uptake of Dietary Iron.

9 citations , November 2007 in “Blood”

This study found that a mutation in the Tmprss6 gene disrupts hepcidin regulation, leading to iron deficiency and alopecia in mice, highlighting TMPRSS6's vital role in iron absorption.

research Matrix-Degrading Type II Transmembrane Serine Protease Matriptase: Its Role in Cancer Development and Malignancy

12 citations , October 2006

This review discusses the role of matriptase and its inhibitor HAI-1 in epithelial homeostasis and cancer development, highlighting their imbalance's link to cancer progression without presenting new experimental results.

research Matriptase: Potent Proteolysis on the Cell Surface

165 citations , January 2006 in “Molecular Medicine”

This review highlights the role of matriptase in epithelial differentiation and cancer, noting that unregulated matriptase expression can enhance cancer progression in animal models, but reports no new experimental data.

research Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis

324 citations , May 2002 in “Oncogene”

research Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

245 citations , January 2010 in “Blood”

This study suggests that antihepcidin antibodies may effectively treat inflammatory anemia by manipulating iron metabolism, based on experiments conducted in mouse models and hHepc knock-in mice.