Response to Li et al.'s 'Therapeutic Efficacy of Platelet-Rich Plasma Combining with Microneedling and Topical Minoxidil in Refractory Severe Androgenic Alopecia'

This review evaluates 21 studies on minoxidil-induced allergic contact dermatitis, finding that some patients with contact dermatitis symptoms like erythema and pruritus are sensitized to minoxidil or its vehicle components and should consider patch testing and alternative formulations for proper management.

This study characterized the activity of naturally occurring minoxidil sulfotransferase enzymes in various plants and found that seven out of ten botanical extracts showed significant activity, suggesting these could potentially enhance minoxidil response in treating androgenetic alopecia.

This study found that applying topical tretinoin can influence follicular sulfotransferase expression, enabling 43% of predicted nonresponders to minoxidil to respond positively in the context of androgenetic alopecia.

This study discusses that while the precise mechanism of minoxidil is not fully understood, its efficacy in stimulating hair growth and treating androgenetic alopecia is well-supported, with evidence showing it increases hair count and hair follicle size in treated patients.

This study found that using minoxidil 2% as a mesotherapy injection showed more significant improvement in treating androgenetic alopecia in female patients than topical application.

This study found that 5% topical minoxidil significantly increased hair regrowth and improved psychosocial perceptions of hair loss in men with androgenetic alopecia compared to 2% topical minoxidil and placebo over 48 weeks.

Topical minoxidil is a safe and effective treatment for hair loss caused by androgenetic alopecia.