Skin Aging And Barrier Dysfunction: Bridging Current Therapies With Future Genetic And Nanotechnological Interventions

This review highlights advancements in skincare aimed at addressing the effects of aging and environmental factors, including new techniques to rejuvenate skin cells and reduce inflammation, though challenges like complex routines and costs limit widespread adoption.

This study explores the complex mechanisms of skin aging, including cellular senescence and disrupted communication, and highlights rejuvenation strategies like gene expression rewiring and microbiome modulation, offering potential frameworks for regenerative therapies and precise interventions in skin and systemic aging.

This review discusses cellular senescence in human skin, detailing both beneficial and detrimental effects and suggesting the potential for therapies targeting senescence-related skin disorders, but reports no new clinical results.

This review highlights new perspectives in genomics and epigenomics for skin rejuvenation, comparing innovative strategies like senolytics and DNA repair modulators with classical treatments, and emphasizing the importance of tailoring therapies using individual genomic profiles for personalized anti-ageing approaches.