PSSD, PFS, PRSD: A Perspective for Aetiology and Treatment

April 2023

Spyridon Bourtzalas

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Post-SSRI Sexual Dysfunction PSSD Post-Finasteride Syndrome PFS Post-Retinoid Sexual Dysfunction PRSD estrogenic activity estrogen receptor estradiol hormonal treatments estrogen hormone therapy

Studysummary This paper introduces a framework attributing Post-SSRI, Post-Finasteride, Post-Retinoid, and an unnamed sexual dysfunction syndrome to downregulated estrogen receptor activity, potentially guiding future treatments in sexual medicine.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer ·

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community So it turns out Post Finasteride Syndrome was never real?

in Finasteride/Dutasteride 271 upvotes 2 years ago

Post Finasteride Syndrome (PFS) is debated, with some users reporting severe side effects from finasteride, while others believe these effects are rare or psychosomatic. Treatments discussed include finasteride, minoxidil, and RU58841.

community Trying to understand finasteride side effects and post finasteride syndrome

70 upvotes 5 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community If you were on finasteride, but experiencing negative symptoms and didn’t know about PFS, would you want someone to tell you?

in Finasteride/Dutasteride 5 months ago

Finasteride users discuss potential side effects, including Post Finasteride Syndrome (PFS), with varying opinions on its legitimacy and impact. Some users report side effects like changes in semen consistency and reduced pre-ejaculate, while others emphasize the rarity and reversibility of side effects.

community if Post Finasteride Syndrome is real. Why is it only the negative effects and not positive have log term effect?

in Finasteride/Dutasteride 63 upvotes 4 months ago

Finasteride is used for hair loss, with mixed reports of no side effects and claims of long-term negative effects known as Post Finasteride Syndrome (PFS). The conversation debates the existence and causes of PFS, with differing opinions on whether it is psychological or real.

community EU Shouldn't Ban Fin & Dut: PFS is NOT REAL.

10 upvotes 1 year ago

Finasteride and Dutasteride do not cause depression or "Post Finasteride Syndrome," with concerns often linked to the nocebo effect and preexisting mental health issues. The EU is unlikely to ban these drugs, but access may become more restricted due to ongoing debates.

community This is lagunaboy and I have fully recovered from PFS

5 upvotes 4 years ago

The user recovered from Post-Finasteride Syndrome (PFS) using a specific hormone protocol after trying finasteride and dutasteride. They now help others with PFS by reviewing blood work and offering personalized advice.

Related Research

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research Testosterone Therapy for Sexual Dysfunction in Postmenopausal Women

46 citations , January 2008 in “Climacteric”

Randomized trials reported that testosterone therapy improved sexual function in postmenopausal women with hypoactive sexual desire disorder, particularly those who had undergone oophorectomy, with reversible and well-tolerated side effects.