The Protective Effects of Apocynin Against Ultraviolet B-Induced Cellular Senescence in Human Keratinocytes
November 2022
in “
Journal of Investigative Dermatology
”
Studysummary This study found that apocynin restored collagen production, reduced DNA damage and senescence, and protected skin stem cells from aging in UVB-exposed human keratinocytes.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study investigated the protective effects of Apocynin, a NADPH oxidase inhibitor, against ultraviolet B (UVB)-induced cellular senescence in human keratinocytes. The researchers found that UVB exposure decreased the production of Type 17 collagen (COL17), a protein crucial for preventing skin aging, and increased cellular senescence. However, pretreatment with Apocynin restored COL17 production and reduced senescence, DNA damage, and cell cycle arrest. The study suggests that Apocynin can protect skin stem cells from aging by reducing DNA damage and senescence, and restoring COL17 production.
