Male Sex Hormone and Reduced Plakoglobin Jointly Impair Atrial Conduction and Cardiac Sodium Currents

    June 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Laura C. Sommerfeld, Andrew P. Holmes, Ting Yu, Christopher O’Shea, Deirdre M. Kavanagh, Jeremy A. Pike, Tom Wright, Fahima Syeda, Areej Aljehani, Tania Kew, Victor Roth Cardoso, S. Nashitha Kabir, Claire Hepburn, Priyanka Menon, Sophie Broadway‐Stringer, Molly O’Reilly, Anika Witten, Lisa Fortmueller, Susanne Lutz, Alexandra Kulle, Georgios V. Gkoutos, Davor Pavlović, Wiebke Arlt, Gareth G. Lavery, Richard P. Steeds, Katja Gehmlich, Monika Stoll, Paulus Kirchhof, Larissa Fabritz
    Studysummary This study found that anabolic steroid use combined with plakoglobin deficiency caused pathological atrial electrical remodeling in young male mice, suggesting a higher risk of atrial myopathy for males with desmosomal gene variants.
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