Consequences of Anabolic-Androgenic Steroid Abuse in Males: Results From a Meta-Analysis Study

    July 2023 in “ ˜The œjournal of sexual medicine ”
    Verena Walter, Bianchi Dr. Nicola, Francesca Fortunato, Giulia Rastrelli, Marchiani Dr. Sara, Sandra Filippi, Morelli Annamaria, Elena Sperk, Di Mario, Alessandra Sereno, Brunetti Dr. Alessandro, Pizzocaro Dr. Alessandro, Maggi Prof. Mario, Giovanni Corona
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    TLDR Anabolic-androgenic steroids harm male hormone levels, sperm, metabolism, and can cause acne, hair loss, and breast growth.
    The meta-analysis study reviewed 24 trials involving 2,411 male patients with a mean age of 29.7 years and a mean follow-up of 148.7 weeks to assess the impact of anabolic-androgenic steroids (AAS) on the male reproductive system. The study concluded that AAS use negatively affects endogenous testosterone production and increases testosterone and estradiol levels, leading to impaired sperm production and the development of side effects such as acne, hair loss, and gynecomastia. Additionally, AAS abuse was associated with a worse metabolic profile, including reduced high-density lipoprotein and increased low-density lipoprotein cholesterol levels, an increased risk of hypertension, and sexual dysfunctions.
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