5α-reductase inhibitors/finasteride
January 1996
in “The Prostate”
TLDR Finasteride is a safe and effective long-term treatment for prostate enlargement, reducing prostate volume and related symptoms.
Finasteride, a 5α-reductase inhibitor, has been shown to be a safe and effective treatment for benign prostatic hyperplasia (BPH). Two multicenter placebo-controlled studies demonstrated that after 12 months of treatment with 5 mg finasteride daily, prostate volume, dihydrotestosterone (DHT) and prostate-specific antigen (PSA) levels were reduced, while maximum urinary flow rates and symptom scores improved. Finasteride was well-tolerated. A long-term study involving approximately half of the patients who were initially treated with 5 mg finasteride for 3 years confirmed the continued safety and efficacy of the drug in the treatment of symptomatic BPH.
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Cited in this study
research Finasteride
Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.
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Finasteride effectively treats BPH but may increase sexual dysfunction risk.
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Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.
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Finasteride effectively blocks enzyme causing male pattern baldness.
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