C19and C215β/5αMetabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency*
March 1990
in “The Journal of Clinical Endocrinology and Metabolism”
TLDR Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.
This study compares the effects of finasteride on male pseudohermaphrodites with inherited 5α-reductase deficiency and normal males. Finasteride reduces 5α-dihydrotestosterone levels and affects plasma testosterone levels and urinary etiocholanolone/androsterone ratios. The study suggests that finasteride may be effective in treating male pattern baldness. Finasteride inhibits 5α-reductase, leading to decreased DHT levels and increased T/DHT ratios in treated subjects. The study found that finasteride reduces DHT levels and affects the metabolism of specific steroids in subjects. Finasteride may be less effective in treating hair loss in individuals with 5α-reductase deficiency.
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Related
research Effect of finasteride, a 5 alpha-reductase inhibitor, on serum gonadotropins in normal men.
Finasteride doesn't affect hormone levels in normal men.