Selective Inhibition of 5α-Reductase and Preservation of Aromatase in Hair Transplantation

    February 2026 in “ Revista Eletrônica Polidisciplinar Voos. ”
    Cristiane das Graças Gavlak
    From the encyclopedia
    Hair Transplant →

    Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.

    Dutasteride →

    Heavy duty finasteride that comes with higher risks

    Saw Palmetto →

    a natural and far less effective alternative to Finasteride

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    Studysummary In this integrative narrative review, researchers reported that aromatase inhibition using dutasteride and Serenoa repens after hair transplant can effectively preserve follicles and minimize side effects, suggesting personalized strategies may optimize clinical outcomes and patient satisfaction.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    This study evaluates post-hair transplant strategies for inhibiting aromatase to enhance follicular growth while minimizing side effects. It reviews 10 articles on the use of dutasteride and Serenoa repens. Results show that aromatase protects transplanted follicles, dutasteride effectively reduces DHT and maintains hair, and Serenoa repens is a safe alternative or adjunct. Personalized strategies using these agents can preserve follicles, minimize side effects, and optimize clinical outcomes, suggesting that a balanced approach to aromatase inhibition is crucial for long-lasting hair transplant success.
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