Sublingual Minoxidil Increases Fiber Diameter in Male Androgenetic Alopecia: A Proxy for Reversal of Hair Follicle Miniaturization

January 2025 in “ PubMed ”

Rodney Sinclair, Justyna Sicińska, Laita Bokhari, Michał Kasprzak

sublingual minoxidil minoxidil male androgenetic alopecia hair follicle miniaturization TrichoLAB H2H analysis SLM MAGA

TLDR Sublingual minoxidil increases hair thickness in men with hair loss.

A study investigated the effects of low-dose sublingual minoxidil (SLM) on hair fibre diameter in 33 men with male androgenetic alopecia (MAGA) over 24 weeks. Using TrichoLAB® H2H analysis, the study found that SLM increased hair fibre diameter in a dose-dependent manner, with the most significant increases observed at doses of 1.35mg and 4.05mg. The increase was particularly notable in intermediate and thickest hairs, suggesting a reversal of hair follicle miniaturization. In contrast, those on placebo experienced a decrease in fibre diameter. The findings support the potential of SLM as a treatment for MAGA by increasing hair fibre diameter and reversing miniaturization.

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