Immortalization of Primary Human Dermal Papilla Cells by Bmi-1 and TERT
October 2017
in “
Journal of Investigative Dermatology
”
hair care products HIROX quantitative image analysis hair surface roughness topical application Stemoxydine Resveratrol hair density fermented mackerel oil hair growth hair-fiber lengths dermal papilla cells wnt/ß-catenin signaling mackerel fermented fish oil UVB-induced oxidative stress human keratinocyte cells immortalization TERT Bmi-1 de novo hair follicles FMO FFO UVB DPCs
TLDR Hair care products reduced hair roughness, a combination of Stemoxydine and Resveratrol increased hair density, fermented mackerel oil promoted hair growth, and genes TERT and Bmi-1 helped create new hair follicles.
The document presents several abstracts related to hair and skin research. Abstract 286 describes a study where 23 female subjects used hair care products for 4 weeks, and the roughness of their hair was measured using HIROX quantitative image analysis. The study found a significant decrease in hair surface roughness after product use. Abstract 288 reports on a study with 79 women aged 25 to 55 who used a topical application of 5% Stemoxydine® and 0.25% Resveratrol for 6 to 12 weeks, resulting in a significant increase in hair density. Abstract 290 investigates the effects of fermented mackerel oil (FMO) on hair growth, showing that FMO significantly increased hair-fiber lengths and the proliferation of dermal papilla cells (DPCs), suggesting the activation of wnt/ß-catenin signaling as a mechanism. Abstract 287 explores the protective effects of mackerel fermented fish oil (FFO) against UVB-induced oxidative stress in human keratinocyte cells. Lastly, abstract 289 discusses the immortalization of primary human dermal papilla cells using the genes TERT and Bmi-1, which led to the induction of de novo hair follicles in vivo. Abstract 291 is marked as withdrawn and does not provide any data.
