Relation of 24-Hour Urinary Aldosterone Levels with Nondipper Blood Pressure Pattern in Normotensive Individuals

    October 2013 in “ Journal of the American College of Cardiology ”
    Ahmet Soylu, Hayrudin Alibasic, Elif Yildirim, Aysun Toker, Halil İbrahim Erdoğan, Mehmet Akif Duzenli, Mehmet Tokaç
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    TLDR Higher aldosterone levels in urine are linked to a nondipper blood pressure pattern in healthy people.
    The study investigated the relationship between 24-hour urinary aldosterone levels and the nondipper blood pressure pattern in normotensive individuals. A total of 85 normotensive participants (office BP <140/90 mmHg, and average 24-hour BP <130/80 mmHg), who were not on any medication and under 60 years of age, were included. The study found that the level of 24-hour urinary aldosterone was significantly higher in the nondipper group compared to the dipper group (9.8 (7.4, 15.5) mgr/day vs. 8.6 (5.0, 11.6) mgr/day, p=0.026). The conclusion drawn from these results was that higher circulating aldosterone levels, as determined by 24-hour urinary aldosterone measurement, are associated with the nondipper blood pressure pattern. This could potentially be a cause of cardiac issues, considering the relationship between aldosterone levels and cardiac fibrosis.
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