High-Frequency (22-MHz) Ultrasound for Assessing the Depth of Basal Cell Carcinoma Invasion

    January 2021 in “ Skin Research and Technology ”
    Elisa de Oliveira Barcaui, Antônio Carlos Pires Carvalho, Paulo Marcos Valiante, Juan Piñeiro‐Maceira, Carlos Baptista Barcauí
    Studysummary This study found that high-frequency ultrasound was effective in localizing deep tumor margins in basal cell carcinoma, suggesting its utility in selecting therapeutic approaches. Our plain-language summary of this paper — not a Tressless recommendation.
    The study evaluated the use of high-frequency ultrasound (HFUS) in assessing the depth of basal cell carcinoma (BCC) invasion by comparing ultrasound images of 83 lesions from 67 patients with histopathological findings. The results showed a strong correlation (r = 0.9744, P < .001) between HFUS and histopathological measurements, with HFUS demonstrating a sensitivity of 96%, specificity of 84%, and accuracy of 91% for measuring deep tumor margins. Factors such as basophilic degeneration of collagen and dense inflammatory changes affected measurements. The study concluded that HFUS was effective in localizing deep tumor margins in BCC, making it a valuable tool in selecting therapeutic approaches and evaluating surgical sites.
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