14 Dermatological Drugs, Topical Agents, and Cosmetics

    January 2007 in “ Side effects of drugs annual
    Sandra Knowles, Gary Wong, Neil H. Shear
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    Studysummary This chapter reviews dermatological treatments, noting that botulinum toxin A is associated with a higher occurrence of focal weakness compared to controls, and reports on adverse effects of finasteride and PUVA therapy.
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    The document reviewed various dermatological drugs, topical agents, and cosmetics, highlighting their uses and associated adverse effects. Botulinum toxin A was used for facial wrinkles and hyperhidrosis, with about 25% of patients experiencing mild to moderate adverse events. VP-eicosene copolymer served as a waterproofing agent in various applications. Contact allergy to 5-aminolaevulinic acid (ALA) was rare, but a case of acute eczema and hyper-reactivity was noted after photodynamic therapy. Acitretin therapy in a 79-year-old man led to capillary leak syndrome with significant edema and hemorrhagic lesions. The document also mentioned adverse effects of psoralens plus UV-A therapy, including non-melanoma skin cancer and pigmentary disorders.
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