One Year Finasteride Therapy in Men with a Serum PSA Greater Than 4 ng/mL Who Had Undergone Repeat Biopsy

    April 2012 in “ The Journal of Urology ”
    Duk Yoon Kim, Yoo Jun Park, Eun Sang Yoo, Hyun Tae Kim, Keun Nam Kim, Young Jin Seo, Joon Chul Kim, Jae Mann Song
    TLDR Finasteride therapy reduces PSA levels and prostate size, helping diagnose prostate cancer.
    The study investigated the effects of one-year finasteride therapy on 40 men with elevated serum PSA levels (>4 ng/mL) and benign prostatic hyperplasia who had undergone repeat biopsies. The results showed significant reductions in PSA levels (46.5%) and prostate volume (24.3%), along with improvements in the International Prostate Symptom Score (IPSS) and maximal flow rate (MFR). Prostate cancer (CaP) was detected in 3 cases (7.5%), and high-grade prostatic intraepithelial neoplasia (HIPIN) in 2 cases (5%). The study concluded that the changes in PSA and prostate volume after finasteride treatment could aid in diagnosing prostate cancer in patients with elevated PSA levels and prior negative biopsies.
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