Is there any role for topical DHT antagonists, or does a 5-AR inhibitor remove the need for them as therapy
    Research/Science 1/6/2025

    At a glance
    In this question or advice post, the primary subjects mentioned are
    ๐Ÿ’Š Finasteride (oral)
    ๐Ÿ’Š Dutasteride (oral)
    ๐Ÿ’ง Topilutamide (topical)
    ๐Ÿ’ง Clascoterone (topical)
    ๐Ÿ’ง Bicalutamide (topical)
    ๐Ÿ’ง Ketoconazole (topical)
    the tone is ๐Ÿ˜ neutral.

    Other terms

    Topical androgen receptor antagonists may not be necessary if 5-AR inhibitors like finasteride or dutasteride effectively reduce DHT levels. Combining a 5-AR inhibitor with a topical androgen antagonist could potentially enhance treatment, but oral use of androgen antagonists is too risky due to severe side effects.
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