DUPA/Retrograde might not be DHT based...GET A BIOPSY QUICK or permanent Hair Loss!
    Research/Science 2/5/2025

    At a glance
    In this educational post, the primary subjects mentioned are
    ๐Ÿ’Š Dutasteride (oral) 0.5mg - 2.5mg once per day
    โ€ข Minoxidil (topical or oral) 5% topical or 0.25mg - 5mg per day
    ๐Ÿ’Š Pioglitazone (oral) 15mg - 30mg once per day
    ๐Ÿ’ง Clobetasol Propionate (topical) 0.05% once per day
    ๐Ÿ’ง Calcipotriol (topical) 0.005% once per day
    โ€ข Ketoconazole (shampoo) 2% 4 times a week
    ๐Ÿ’Š Doxycycline (oral) 200 mg once or twice a day
    the tone is ๐Ÿ˜ neutral.

    Other terms

    DUPA and retrograde alopecia may not be solely DHT-based, and a biopsy is crucial for accurate diagnosis and treatment. Treatments mentioned include dutasteride, oral minoxidil, pioglitazone, clobetasol, calcipotriol, ketoconazole, and doxycycline, depending on the specific condition.
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      by nkrata in Research  830 upvotes 6 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      by thogory in Treatment  111 upvotes 5 months ago
      The user has experienced significant hair thinning despite using 2.5 mg minoxidil for 2 years. Other users suggest adding finasteride or dutasteride and consulting a dermatologist for a proper diagnosis.
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      by Methorubeit in Progress Pictures  46 upvotes 10 months ago
      A 25-year-old has used minoxidil for 7 years, finasteride for 2 years, oral minoxidil and dutasteride for 3 months, and also tried microneedling and nizoral. They are considering a hair transplant but are concerned about being a good candidate due to potential retrograde alopecia.

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      by Combfromhell in Finasteride/Dutasteride  251 upvotes 1 year ago
      The user tried dutasteride for hair loss for 2.5 years but experienced drastic thinning and receding hairline. They decided to switch back to finasteride, along with minoxidil, LLLT, and ketoconazole, due to dissatisfaction with dutasteride's results and side effects.

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