Joining clinical study for Clascoterone (Breezula)
    Research/Science 1/14/2025

    From the encyclopedia
    Clascoterone →

    a novel topical treatment that inhibits DHT on androgen receptors

    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

    At a glance
    In this question or advice post, the primary subjects mentioned are
    💧 topical finasteride (topical) 1 year
    💧 minoxidil (topical) 1 year
    💊 oral finasteride (oral) 0.5mg 3 months
    the tone is 😐 neutral with no results.

    Other terms

    The conversation is about a user considering joining a clinical study for Clascoterone (Breezula) after experiencing no results with topical finasteride and minoxidil, and side effects from oral finasteride. The user is seeking advice on clinical study participation and experiences.
    View this post in the Community →

    Similar Community Posts Join

    5 / 5 results

      community Stopping fin after 1.8 Years??!!

      in Finasteride/Dutasteride  10 upvotes 9 months ago
      The user is considering stopping finasteride after 1.8 years due to concerns about side effects and is exploring alternatives like minoxidil and topical finasteride. They are also considering microneedling and are advised to wait for new treatments like breezula/clascoterone.

      community Breezula - who tried CB0301/Clascoterone from gray marked/pharmas ?

       1 upvotes 7 months ago
      The conversation discusses using CB0301/Clascoterone as a potential treatment for hair loss, especially for those experiencing side effects from finasteride and dutasteride. The user currently uses oral minoxidil and considers combining it with other treatments like kx826, DHT blocker supplements, and 2% Nizoral shampoo.

      community Can anyone give me a quick 2026 update of the most promising new hair loss drugs to come?

       47 upvotes 2 months ago
      New hair loss treatments like Breezula and a version of Minoxidil for hair regrowth are in advanced trials and may be available in a few years. Clascoterone and other treatments like oral and topical Minoxidil, Finasteride, and Dutasteride are also discussed, with some users experiencing side effects from Finasteride.

      community What do we currently know about clascoterone?

       7 upvotes 8 months ago
      Clascoterone is seen as a promising topical treatment for hair loss, similar to finasteride but without side effects, though concerns exist about its long-term effectiveness. Other treatments discussed include topical minoxidil, ketoconazole, microneedling, and oral options like dutasteride and minoxidil.

      community Why is everyone still arguing about PP405 when clascoterone is already heading toward regulatory submission?

       46 upvotes 1 month ago
      Clascoterone is nearing regulatory submission as a potential new treatment for androgenetic alopecia, with positive Phase III results, while discussions continue about other treatments like PP405, minoxidil, and finasteride. Some users express excitement for clascoterone and Breezula, despite concerns about the effectiveness and practicality of topical treatments.

    Related Research

    6 / 6 results
      New Drugs Under Investigation for the Treatment of Alopecias

      research New drugs under investigation for the treatment of alopecias

      26 citations , January 2019 in “Expert Opinion on Investigational Drugs”
      This review explored the new and emerging treatments for androgenetic alopecia and alopecia areata, finding that JAK inhibitors show promise for alopecia areata, while advancements in stem-cell research may eventually lead to new and improved treatments for androgenetic alopecia.
      Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris

      research Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris

      7 citations , December 2019 in “American Journal of Clinical Dermatology”
      This review discusses the potential efficacy of topical antiandrogen therapies for treating androgenetic alopecia and acne vulgaris, finding promising results but highlighting the need for more comprehensive studies.
      Androgenetic Alopecia: An Update Of Treatment Options

      research Androgenetic Alopecia: An Update of Treatment Options

      110 citations , August 2016 in “Drugs”
      Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.
      New Therapeutics in the Management of Androgenetic Alopecia

      research Nouvelles thérapeutiques dans la prise en charge de l’alopécie androgénétique

      March 2025 in “HAL (Le Centre pour la Communication Scientifique Directe)”
      This thesis investigates the underlying mechanisms and treatment options for androgenetic alopecia, highlighting the molecular roles of androgens and genetic predispositions, and evaluates current and emerging therapies, such as PROTACs and Janus Kinase inhibitors, to enhance patient management.
      Antiandrogens and Androgen Inhibitors in Dermatologic Treatments

      research Antiandrogens and Androgen Inhibitors

      November 2020 in “Elsevier eBooks”
      This source outlines various antiandrogen and androgen inhibitor drugs used to treat cutaneous disorders of hyperandrogenism, detailing their mechanisms, uses, dosages, and side effects, with emphasis on spironolactone, finasteride, dutasteride, and oral contraceptives.