Any users using either RU or Pyrilutamide from Actifolic? How’s your experience? Product 9/14/2022
Treatments for hair loss, specifically discussing the use of RU58841 and Pyrilutamide from Actifolic. The poster is inquiring about experiences with these products and results.
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5 / 1000+ resultscommunity pyrilutamide solution progress log
A 28 year old using a hair loss prevention protocol to restore thinning hair, which includes finasteride, dutasteride, minoxidil, stemoxydine, alopecin, nizoral shampoo and microneedling; the user is now adding pyrilutamide solution to the regimen with the hope of improving their results. RU58841 was also ordered but not yet used.
community What’s your experience with RU58841?
People shared mixed experiences with RU58841 for hair loss; one person saw no improvement, another had significant gains and uses it with finasteride, while a third had an allergic reaction to the premixed solution. Some mix RU58841 powder into minoxidil themselves.
community [Research/Science] What's the General Consensus On Pyrilutamide So Far?
Pyrilutamide is considered to work for hair loss but less effectively than expected, similar to RU58841, and may cause side effects like chest tightness and sexual issues. It's unclear if it's suitable for diffuse thinners, and one user cannot use minoxidil or finasteride due to side effects and personal circumstances.
community My Pyrilutamide Experience so far
A user's experience with Pyrilutamide for hair loss, which has been successful in reversing receding hairline when part of their stack with other treatments such as Dutasteride, Minoxidil, and Ketoconazole shampoo.
community I think it’s time to drop Pyrilutamide at this point?….
A user who has been using Pyrilutamide for 5 months with no results, and other users suggesting they switch to RU58841 or stick to their treatment plan for at least one year.
Related Research
6 / 88 results
research Dose-Dependent and Long-Term Effects of RU58841 (Androgen Receptor Blocker) on Hair Growth in the Bald Stumptailed Macaque
RU58841, an androgen receptor blocker, significantly increased hair density, thickness, and length in monkeys when applied topically daily for several months.

research Evaluation of RU58841 as an Anti-Androgen in Prostate PC3 Cells and a Topical Anti-Alopecia Agent in the Bald Scalp of Stumptailed Macaques
RU58841, a nonsteroidal anti-androgen, showed potential as a topical treatment for hair loss, increasing hair density, thickness, and length without systemic side effects in Stumptailed Macaques.

research The Effect of Topical RU58841 (Androgen Receptor Blocker) Combined with Minoxidil on Hair Growth in Macaque Androgenetic Alopecia
Combining RU58841 and minoxidil significantly increases hair growth.

research Alternative Synthesis of the Anti-Baldness Compound RU58841
A new, less toxic and more efficient method to create the anti-baldness compound RU58841 was developed in 2014.

research Clinical Updates in Hair
Most treatments for hair loss in 1997 were not effective for most people, and maintaining hair growth was difficult.

research Significance of RU58841 as a Therapeutic Agent Affecting Androgen Receptor Molecular Interactions in Human Hair Follicles
RU58841, a substance from France, can potentially block the effects of hormones that cause hair loss and excessive hair growth, performing better than a similar substance, cyproterone acetate.