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    New Featured Research

    Spatiotemporal atlas resolves the mesenchymal-epithelial stem cell axis governing human hair follicle aging and pathology

    This study explores how mesenchymal and epithelial stem cells in hair follicles coordinate hair regeneration and how these processes change with aging and androgenetic alopecia (AGA). The researchers used a spatiotemporal atlas and functional validation to understand these dynamics. They found that aging leads to a passive depletion of regenerative signals from human dermal sheath cells (hDSC), while AGA causes hDSC to shift towards inhibitory signaling, impairing hair follicle stem cell (HFSC) function. The study identifies hDSC-secreted pleiotrophin (PTN) as a crucial factor that promotes hair growth and counteracts the growth suppression caused by androgens. This research provides a comprehensive framework for understanding stem cell interactions in hair follicle aging and pathology, offering insights for restoring tissue regeneration.

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    New in research

    1. Integrated Evaluation of Umbilical Cord Mesenchymal Stromal Cell-Derived Extracellular Vesicles Across Skin-Related Cellular and Zebrafish Models

      This study found that human umbilical cord mesenchymal stromal cell-derived extracellular vesicles improved several skin-related processes, including reducing oxidative injury, enhancing wound repair, and modulating androgen-related responses, in various cellular and zebrafish models.

    2. The Hyperandrogenism in Female Athletes: When Dermatological Signs Become an Endocrine and Sports Medicine Challenge

      This review discusses hyperandrogenism in female athletes, focusing on dermatological indicators for diagnosis and emphasizing the need for a multidisciplinary approach to manage the condition effectively.

    3. Graft Survival by Norwood-Hamilton Stage: A Stratified Outcome Analysis of Follicular Unit Extraction Patients at Vera Clinic (2020–2025)

      This study found that graft survival rates after follicular unit extraction varied significantly across different stages of androgenetic alopecia, suggesting the NH stage may influence surgical outcomes.

    4. Development of Collagen-Like Peptide Hydrogel Biomaterials for Soft Tissue Repair

      This study suggests that peptide-based hydrogels are a promising platform for repairing soft tissue in the skin, cornea, and heart, demonstrating benefits in wound healing and myocardial infarction in a mouse model.

    5. Prevalence of Metabolic Syndrome in Patients With Androgenetic Alopecia: An Analysis of Current Evidence

      This study found that metabolic syndrome and several metabolic abnormalities are common among patients with androgenetic alopecia, with prevalence estimates varying significantly across different studies.

    6. GCN5-Mediated H3K27cr Regulates Hair Follicle Stem Cell Migration and Hair Follicle Development Through KRT80 Activation

      This study found that GCN5-mediated H3K27 crotonylation targets KRT80 in cashmere goats, promoting secondary hair follicle stem cell migration during hair follicle development.

    7. Editorial: Update in Trichology and Hair Transplantation

      This review explores contemporary trichology, focusing on advanced diagnostic methods and treatment strategies for hair and scalp disorders, but it reports no new clinical results and calls for more evidence-based studies.

    8. Low-Dose Oral Versus Topical Minoxidil in Androgenetic Alopecia: A Randomized, Double-Blind, Double-Dummy Controlled Trial

      This randomized controlled trial found that both topical and low-dose oral minoxidil improved androgenetic alopecia, but did not establish non-inferiority or equivalence between the treatments.

    9. Beyond Hirsutism: Hair Phenotypes as Clinical Signals for the Recognition of Polyendocrine Metabolic Ovarian Syndrome: A Scoping Review Protocol

      This review discusses the potential of integrated hair phenotypes as clinical signals for recognizing the recently renamed PMOS (formerly PCOS) and reports no new results; the authors emphasize the need for systematic mapping.
    View more new articles in Research →

    New in community

    1. 23M Minoxidil + Finasteride 5 month progress

      A 23-year-old male shares his 5-month progress using oral finasteride, topical minoxidil, ketoconazole shampoo, and microneedling for hair regrowth, noting improvement from Norwood 3 to Norwood 2 with no side effects. He attributes most regrowth to minoxidil and feels better about his hair loss.

    2. 1-Year(ish) Journey with Oral Fin and Min

      The user shared their experience with oral finasteride and minoxidil for hair loss, noting initial improvement but experiencing setbacks after inconsistent use. Despite resuming the medication, they faced renewed shedding and are seeking insights into the fluctuating progress.

    3. Never give up! 1mg finasteride for the past year

      The conversation is about a user sharing their positive experience using 1mg finasteride for hair loss over the past year, claiming no side effects. Other users question the validity of the progress photos due to different lighting and angles.

    4. Hairloss Progress (August 2024-September 2026)

      The user shared their hair loss journey, starting with Minoxidil in August 2024 and adding Finasteride in September 2025, noting significant improvement after adding Finasteride. They also mentioned using MCT oil for Seborrheic Dermatitis and encouraged consistency in treatment.

    5. Hair Transplant in Poland vs Turkey

      A UK man considering a hair transplant is weighing options between Poland and Turkey, citing familiarity and perceived safety in Poland. He has been using minoxidil, microneedling, and finasteride but hasn't seen major improvements, and is advised to prioritize choosing a skilled surgeon over focusing on the country or cost.

    6. 3 months on Topical Min,Fin,Tre.

      A 47-year-old male is using topical minoxidil, finasteride, and tretinoin for hair loss, showing early progress with plans to continue for 12 months before considering a hair transplant. Users encourage consistency and note visible improvements.

    7. Hair has gotten much worse since starting Fin

      A 22-year-old experienced worsening hair loss after starting finasteride and reducing minoxidil dosage, considering a hair transplant but unsure due to potential hair regrowth. Suggestions include testing DHT levels, possibly switching to dutasteride, and consulting a dermatologist for a comprehensive diagnosis.

    8. Hereditary hair loss want your advice

      Minoxidil and finasteride/dutasteride are recommended for treating hereditary hair loss, with vitamin D as a supplement if deficient. The suggested treatment plan from the clinic is considered expensive and unnecessary, with a second opinion advised.

    9. 3 month Dut .1mg 1.1fin 5mg oral minoxidil plus topical.

      The user started a hair loss treatment in June using 0.1mg dutasteride, 1.1mg finasteride, 5mg oral minoxidil, and topical minoxidil. They report good progress with no significant side effects, except for some unwanted hair growth on the face and hands.
    View more new posts in Community →