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    New Featured Research

    Spatiotemporal atlas resolves the mesenchymal-epithelial stem cell axis governing human hair follicle aging and pathology

    This study explores how mesenchymal and epithelial stem cells in hair follicles coordinate hair regeneration and how these processes change with aging and androgenetic alopecia (AGA). The researchers used a spatiotemporal atlas and functional validation to understand these dynamics. They found that aging leads to a passive depletion of regenerative signals from human dermal sheath cells (hDSC), while AGA causes hDSC to shift towards inhibitory signaling, impairing hair follicle stem cell (HFSC) function. The study identifies hDSC-secreted pleiotrophin (PTN) as a crucial factor that promotes hair growth and counteracts the growth suppression caused by androgens. This research provides a comprehensive framework for understanding stem cell interactions in hair follicle aging and pathology, offering insights for restoring tissue regeneration.

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    New in research

    1. Integrated Evaluation of Umbilical Cord Mesenchymal Stromal Cell-Derived Extracellular Vesicles Across Skin-Related Cellular and Zebrafish Models

      This study found that human umbilical cord mesenchymal stromal cell-derived extracellular vesicles improved several skin-related processes, including reducing oxidative injury, enhancing wound repair, and modulating androgen-related responses, in various cellular and zebrafish models.

    2. The Hyperandrogenism in Female Athletes: When Dermatological Signs Become an Endocrine and Sports Medicine Challenge

      This review discusses hyperandrogenism in female athletes, focusing on dermatological indicators for diagnosis and emphasizing the need for a multidisciplinary approach to manage the condition effectively.

    3. Graft Survival by Norwood-Hamilton Stage: A Stratified Outcome Analysis of Follicular Unit Extraction Patients at Vera Clinic (2020–2025)

      This study found that graft survival rates after follicular unit extraction varied significantly across different stages of androgenetic alopecia, suggesting the NH stage may influence surgical outcomes.

    4. Development of Collagen-Like Peptide Hydrogel Biomaterials for Soft Tissue Repair

      This study suggests that peptide-based hydrogels are a promising platform for repairing soft tissue in the skin, cornea, and heart, demonstrating benefits in wound healing and myocardial infarction in a mouse model.

    5. Prevalence of Metabolic Syndrome in Patients With Androgenetic Alopecia: An Analysis of Current Evidence

      This study found that metabolic syndrome and several metabolic abnormalities are common among patients with androgenetic alopecia, with prevalence estimates varying significantly across different studies.

    6. GCN5-Mediated H3K27cr Regulates Hair Follicle Stem Cell Migration and Hair Follicle Development Through KRT80 Activation

      This study found that GCN5-mediated H3K27 crotonylation targets KRT80 in cashmere goats, promoting secondary hair follicle stem cell migration during hair follicle development.

    7. Editorial: Update in Trichology and Hair Transplantation

      This review explores contemporary trichology, focusing on advanced diagnostic methods and treatment strategies for hair and scalp disorders, but it reports no new clinical results and calls for more evidence-based studies.

    8. Low-Dose Oral Versus Topical Minoxidil in Androgenetic Alopecia: A Randomized, Double-Blind, Double-Dummy Controlled Trial

      This randomized controlled trial found that both topical and low-dose oral minoxidil improved androgenetic alopecia, but did not establish non-inferiority or equivalence between the treatments.

    9. Beyond Hirsutism: Hair Phenotypes as Clinical Signals for the Recognition of Polyendocrine Metabolic Ovarian Syndrome: A Scoping Review Protocol

      This review discusses the potential of integrated hair phenotypes as clinical signals for recognizing the recently renamed PMOS (formerly PCOS) and reports no new results; the authors emphasize the need for systematic mapping.
    View more new articles in Research →

    New in community

    1. 10 month check in min+fin 30.5 year old

      The user has been using 1mg oral finasteride and 5% topical minoxidil for 10 months with noticeable progress in hair growth. Suggestions include adding microneedling, red light laser therapy, and considering switching to dutasteride for potentially better results.

    2. A practical checklist for comparing hair transplant clinics before deciding

      Hair Transplants
      When comparing hair transplant clinics, consider factors beyond price and graft count, such as surgeon involvement, donor area assessment, technique, aftercare, and what's included in the price. Use a checklist to evaluate clinics and avoid pressure tactics or vague information.

    3. There's hope for us, boys! Don't despair!

      Some people find baldness attractive, and preferences vary. Treatments like Minoxidil and finasteride are mentioned, but personal acceptance and confidence are emphasized.

    4. Question: how do you tell when two hair-loss stories are actually comparable?

      Comparing hair loss stories is challenging due to individual differences in genetics and treatment responses, making direct comparisons often unhelpful. The conversation suggests focusing on personal progress rather than seeking exact matches in others' experiences.

    5. I’m about to lose most of my progress

      The conversation is about a person concerned about losing hair progress due to stopping finasteride and minoxidil while joining the navy. Suggestions include taking a high dose of dutasteride before leaving, as it stays in the system longer, and reassurance that progress may not be significantly affected.

    6. Is “hims” a good option for hair loss?

      Basic Questions
      Hims offers treatments like Minoxidil and finasteride for hair loss. Users discuss their experiences and results with these products.

    7. Second Shed on Oral Min+Fin: Retrograde Thinning Concern

      Basic Questions
      Image The user has been using oral minoxidil and finasteride for about eight months and is experiencing a second shedding phase, with improvements in the temples but concerns about thinning at the back of the head. They are unsure if this is retrograde thinning, as there is no family history of it.

    8. 23M Minoxidil + Finasteride 5 month progress

      A 23-year-old male shares his 5-month progress using oral finasteride, topical minoxidil, ketoconazole shampoo, and microneedling for hair regrowth, noting improvement from Norwood 3 to Norwood 2 with no side effects. He attributes most regrowth to minoxidil and feels better about his hair loss.

    9. 1-Year(ish) Journey with Oral Fin and Min

      The user shared their experience with oral finasteride and minoxidil for hair loss, noting initial improvement but experiencing setbacks after inconsistent use. Despite resuming the medication, they faced renewed shedding and are seeking insights into the fluctuating progress.
    View more new posts in Community →