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New in community
- Featured Community Post
Research Backed Dutasteride Simulator (Serum/scalp DHT included for all doses)
A Dutasteride Simulator predicts serum dutasteride, serum DHT, and scalp DHT levels using models from research papers. It simulates various dosing schedules to determine steady-state effects and visualizes outcomes, including hair growth-related scalp DHT suppression.
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Well still bother me
General The user has been using minoxidil for 6 months and has seen improvements but still has bald spots. They plan to consult a dermatologist to address their concerns. -
27M, Using Minoxidil for 5 Months, Considering Finasteride – How to Assess Responsiveness?
General A 27-year-old male has been using minoxidil for five months with no improvement and is considering adding finasteride to address potential DHT interference. He is seeking advice on whether finasteride might enhance minoxidil's effectiveness or if he should consider other options like a hair transplant. -
Progress 3 months oral Finasteride + 6 months topical Minoxidil
Progress Pictures The user experienced significant hair improvement after 3 months of oral finasteride and 6 months of topical minoxidil, with additional weekly microneedling. Hair shedding decreased significantly with no side effects reported. -
Dec 2024 vs now (min + fin/dut)
Progress Pictures The user experienced hair thickening and reduced shedding using minoxidil, finasteride, and dutasteride, with a switch from finasteride to dutasteride due to ineffectiveness. They also use a saw palmetto shampoo and take vitamin D3 supplements, while considering potential underlying causes like vitamin deficiencies and hard water buildup. -
Novel Formulation To Put An End To Hair Loss Once And For All.
Research/Science A pharmacy student proposed a hair loss treatment using minoxidil, finasteride, clascoterone, and tretinoin, aiming for high effectiveness with minimal side effects. Reactions were mixed, with some questioning its feasibility and others showing interest. -
18M Using Finasteride and Minoxidil: No Improvement in Hair Density Since February
Finasteride An 18-year-old using finasteride since February and minoxidil since July has not seen improvement in hair density. They are advised to continue treatment as results can take up to a year, and to consider other options if no change occurs after a full year.
New Featured Research
Using the Mechanisms of Action Involved in the Pathogenesis of Androgenetic Alopecia to Treat Hair Loss
The document reviews the pathogenesis and treatment of androgenetic alopecia (AGA), emphasizing the roles of genetic and androgenic factors, particularly dihydrotestosterone (DHT) and androgen receptors, in hair follicle miniaturization. Current FDA-approved treatments, Minoxidil and Finasteride, are effective but require lifelong use. New pharmacological therapies targeting AGA's mechanisms, such as growth factors like IGF-1 and VEGF, are explored for potentially more effective treatments. Combining drugs has shown better outcomes, as demonstrated in studies where combinations like Minoxidil and Finasteride significantly improved hair growth. A study with 40 men using a combined topical treatment (TH07) showed promising results, with 52% experiencing dense hair growth. Overall, these treatments are well-tolerated, with no significant adverse effects reported.
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New in research
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Hyperandrogenism Insulin Resistance-Acanthosis Nigricans Syndrome in a Female Adolescent with Migraine: A Case Report
Early diagnosis and treatment of endocrine disorders like HAIR-AN syndrome can improve outcomes in adolescents.
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Effects of GLP-1 Receptor Agonists on Hair Loss and Regrowth: A Systematic Review
GLP-1 receptor agonists may cause hair loss, but regrowth is rare.
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Psoriasis and Alopecia: Unveiling the Links
Psoriasis patients are more likely to develop alopecia areata due to complex autoimmune interactions.
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Dermatological Alterations Induced by Gynecological Hormonal Imbalances: Acne, Hirsutism, and Alopecia
Hormonal imbalances can cause acne, excess hair growth, and hair loss in women, needing combined medical and emotional care.
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Amitriptyline-Induced Telogen Effluvium in a Patient with Cervical Disc Prolapse: A Case Report
Amitriptyline can cause temporary hair loss, which stops after discontinuing the drug.
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Associations Between GLP-1 Receptor Agonists and Alopecia: A Multi-Center Retrospective Analysis and Public Interest Trends
GLP-1 receptor agonists may increase the risk of a specific type of hair loss called androgenetic alopecia.
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Prevalence and Hormonal Profiling of Secondary Amenorrheic Patients Presenting to a Fertility Clinic – An Observational Study
Hyperprolactinemia is the most common cause of secondary amenorrhea, followed by drug use.
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Exosome-Based Therapies for Androgenetic Alopecia: Mechanisms, MicroRNAs, and Clinical Prospects
Exosome therapy could be a promising new way to treat hair loss.
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The Legacy of Bruce Ames and Mitochondrial DNA Mutagenicity: Integrating Oxidative Stress, Aging, and Modern Perspectives
Bruce Ames's work has greatly influenced research on genetics, aging, and health, inspiring ongoing studies on mitochondria and longevity.