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New in community
- Featured Community Post
Research Backed Dutasteride Simulator (Serum/scalp DHT included for all doses)
A Dutasteride Simulator predicts serum dutasteride, serum DHT, and scalp DHT levels using models from research papers. It simulates various dosing schedules to determine steady-state effects and visualizes outcomes, including hair growth-related scalp DHT suppression.
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Update July 2025] Most Promising Hair Loss Treatments in Clinical Trials
Research/Science Promising hair loss treatments in clinical trials include Pyrilutamide, GT20029, CB-03-01, and PP405, with potential market releases between 2027 and 2029. Hair cloning remains experimental and expensive, while existing treatments like finasteride, minoxidil, and microneedling continue to be used. -
1600 grafts (~5500 hairs) | 10 month results
Transplants The user received 1600 hair grafts but is dissatisfied and plans a second transplant for better coverage. They use minoxidil and finasteride and are considering adding dutasteride. -
2 Years on Fin — Early Gains, Acne Flare, and Ongoing Scalp Sensitivity
Finasteride The user has been on finasteride for over two years, experiencing early hair regrowth, acne, and scalp sensitivity, but now faces thinning hair and questions about dosage and long-term effectiveness. They also used retinal to help with acne and are seeking advice on whether to adjust their finasteride dose. -
ED from 1 month DUT
General A 32-year-old male experienced reduced libido and erectile difficulties after taking Minoxidil and Dutasteride for hair loss. He stopped the treatment and plans to consult his doctor, seeking similar experiences from others. -
How do I consult a hair specialist for medicines? (Germany)
General An international student in Germany needs a prescription for finasteride and minoxidil to continue treating androgenic alopecia. They seek guidance on finding a doctor and using their student health insurance for the prescription. -
1 Year Oral Finasteride + Minoxidil Results — No Microneedling or Other Treatments Used
Progress Pictures A 23-year-old used daily oral finasteride (1.1mg) and minoxidil (3mg) for a year, resulting in significant hair regrowth, especially at the left temple, and increased eyebrow density. The user experienced mild initial shedding and itchiness but no other treatments were used, and libido normalized quickly after a slight initial dip.
New Featured Research
Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C
This study investigates hair pigmentation mechanisms using mouse skin organoids, focusing on melanocyte behavior. It identifies COL6A3 (Collagen type VI alpha 3 chain) and SEMA3C (Semaphorin 3C) as key factors in melanocyte function. COL6A3, secreted by fibroblasts, supports melanocyte maintenance and proliferation, while SEMA3C enhances adaptive patterning during hair regeneration. The COL6A3-CD44 signaling pathway is crucial for melanocyte survival, with CD44 inhibition reducing pigmentation effects. Additionally, the SEMA3C-NRP1 axis promotes melanocyte recruitment, enhancing hair pigmentation. These findings suggest potential therapeutic strategies for pigmentation disorders, though limitations in replicating human conditions indicate a need for advanced humanized organoid systems in future research.
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New in research
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Use of 5% Topical Minoxidil Application for Telogen Effluvium: An Open-Label Single-Arm Clinical Trial
5% topical minoxidil may help reduce hair loss and increase hair growth in telogen effluvium.
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Ultrasound-Activated GelMA Hydrogel Loaded with MSC-EVs Promotes Functional Regeneration of Skin Vasculature, Nerves, and Appendages
Ultrasound-activated gel with stem cell vesicles improves skin healing and regeneration.
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Fermented Grapeseed Oil Repairs Chemically Damaged Hair Via Enhanced Permeability Mechanisms
Fermented grapeseed oil effectively repairs and protects chemically damaged hair.
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A Polyherbal Approach to Hair Care: Development and Evaluation of a Solid Shampoo Bar
The polyherbal solid shampoo bar is an effective, safe, and eco-friendly hair care option.
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Effectiveness of Autologous Platelet-Rich Plasma for Androgenetic Alopecia: A Double-Center, Non-Controlled, Randomized Clinical Study in Vietnam
PRP therapy effectively improves hair density and reduces hair loss in androgenetic alopecia.
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Botulinum Toxin for Treatment of Androgenetic Alopecia
Botulinum toxin is not proven effective for treating hair loss.
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Safety Profile and Efficacy of Biosea Revive Serum for Hair Growth Through In Vitro Assessment and Clinical Evaluation
Biosea® Revive Serum is safe and effective for improving hair growth and health.
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Mesenchymal Stem Cell-Derived Exosomes Can Effectively Improve Hair Count and Terminal Hair Diameter in Androgenetic Alopecia
Stem cell exosome injections can safely improve hair growth and thickness in men with hair loss.
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Comparative Efficacy of Minoxidil and 5-Alpha Reductase Inhibitors Monotherapy for Male Pattern Hair Loss: Network Meta-Analysis Study of Current Empirical Evidence
Dutasteride 0.5 mg/day is the most effective treatment for male pattern hair loss.