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Genetic defects in the Wnt/PCP pathway may cause congenital yellow nail syndrome.

Hair regrowth was seen in 83% of children with alopecia, immune system plays a role in the condition, and various treatments showed effectiveness for hair and nail disorders.

HIV can cause various nail and hair disorders, important for early diagnosis and treatment.

In this narrative review, researchers found preliminary evidence suggesting that minoxidil, both topical and oral, may enhance nail growth and improve nail strength and appearance, though more extensive studies are needed to confirm its efficacy and safety for this off-label use.

This article reviews the history and medical literature on minoxidil, highlighting its approved topical use for hair disorders like androgenic alopecia and potential new applications, such as in yellow nail syndrome and vitiligo treatment alongside phototherapy.