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research A Mouse Model for the Basal Transcription and DNA Repair Syndrome Trichothiodystrophy

188 citations , June 1998 in “Molecular cell”

Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.

research Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss

688 citations , June 2007 in “Cell Stem Cell”

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

research New Clinico-Genetic Classification of Trichothiodystrophy

68 citations , August 2009 in “American Journal of Medical Genetics Part A”

A new classification for trichothiodystrophy helps identify genetic causes and potential treatments.

research Replicative Stress, Stem Cells, and Aging

70 citations , March 2008 in “Mechanisms of Ageing and Development”

Maintaining DNA health in stem cells is key to preventing aging and tissue breakdown.

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