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Research

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research 354 Investigating early molecular changes in a model of x-ray radiation-induced alopecia: spotlight on growth arrest and endothelial dysfunction

November 2025 in “Journal of Investigative Dermatology”

Radiation-induced hair loss may be caused by hair growth stopping and inflammation in blood vessels.

research Leveraging Multifaceted Polyphenol Interactions: An Approach for Hair Loss Mitigation

January 2025 in “Advanced Materials Interfaces”

This study observed that tannic acid significantly reduced hair shedding by 56.2% over seven days in human participants when used as a coating for controlled release of active compounds to hair follicles.

research Silicon in hair loss: a preliminary SEM microanalysis study

4 citations , February 2007 in “Journal of the European Academy of Dermatology and Venereology”

This article discusses silicon in hair loss but provides no new research findings or clinical results.

research Scanning Electron Microscopy and X-ray Microanalysis of Reconstructive Hair Fibers.

1 citations , January 2017 in “PubMed”

This study found that despite chemical differences, five different brands of reconstructive hair fibers all provided successful cosmetic results in disguising hair loss in patients.

Diagnosis and Treatment of Alopecia in an Older Dog with Abdominal Mass

research What was your diagnosis?

1 citations , November 1998 in “Journal of Small Animal Practice”

This article presents a diagnostic case in the Journal of Small Animal Practice and reports no new research findings.

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Community Join

5 / 504 results

community Do PUFA's accelerate hair loss? Is this tweet accurate?

4 months ago

PUFA foods like salmon and walnuts are healthy and do not accelerate hair loss. There is no evidence linking PUFAs to hair loss, and claims suggesting otherwise lack scientific support.

community I think I’ve finally found the reason for my hair loss

in Chat 98 upvotes 1 year ago

The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.

community I am putting my hair loss treatment on hold until my mental health is better.

in Update 21 upvotes 2 years ago

OP is pausing hair loss treatments to focus on mental health due to anxiety and side effects from RU58841. They plan to try topical finasteride and minoxidil after recovering from pneumonia.

community Subcutaneous Scalp fat and Hair loss? Interested in others annecdotal experience or knowledge.

6 upvotes 3 years ago

Subcutaneous scalp fat may be linked to hair loss, with theories suggesting that fat loss can lead to reduced blood flow and increased DHT activity, contributing to hair loss. Treatments discussed include PRP/PRF injections and fat transfer to improve scalp thickness and blood flow.

community Let’s get PP405 trending on Twitter!

in Chat 69 upvotes 1 year ago

People are excited about a new hair loss treatment, PP405, and some suggest using Twitter to increase its visibility. Current treatments mentioned include finasteride, minoxidil, and dutasteride, but skepticism remains about the effectiveness of new treatments.

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Clinics

6 / 6 results

Learn

9 / 801 results

learn Alfatradiol

Alfatradiol: Can it help if my hair loss is linked to DHT? The one randomised trial of topical alfatradiol — in 103 women — found hair thickness and density essentially unchanged after six months, while minoxidil improved both; its authors credited alfatradiol with slowing hair loss rather than regrowing hair. Laboratory work supports a local effect on follicular DHT, but no controlled trial in men appears to have been published.
Alfatradiol: What does a form of estrogen have to do with hair loss in men? Alfatradiol (17α-estradiol) is a prescription topical hormone, licensed for androgenetic alopecia in Germany but not FDA-approved. The controlled trial evidence is in women, where it produced stabilisation rather than regrowth and was outperformed by minoxidil; no comparable placebo-controlled trial in men appears to have been published.

learn RU58841

Will I lose my hair if I stop using RU58841? (Spoiler: I might.) There is no published human trial of stopping RU58841; community members commonly report shedding within weeks to months, and androgen biology suggests miniaturization would resume once the topical anti-androgen is withdrawn.

learn KX-826

Kintor Pharmaceutical: KX-826, a New Name in Hair Loss Research KX-826 (pyrilutamide) is an experimental topical androgen receptor blocker from Kintor Pharmaceutical. It is not approved as a medicine anywhere; the company reports that its China Phase III trial met its primary endpoint at 24 weeks, but the trial data has been released through corporate announcements rather than peer-reviewed journals and long-term safety is unknown.

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

learn vitamin A

Are you unknowingly overdoing vitamin A? It could be speeding up hair loss linked to hormones like DHT. Sustained vitamin A intake above the tolerable upper limit (3,000 mcg/day of retinol for adults) is linked in case reports to diffuse hair shedding; the claim that it amplifies DHT-driven hair loss has no published human evidence behind it.

learn Hair Transplant

Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.

learn Tretinoin

the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

learn Adenosine

nucleoside used for hair regrowth stimulant properties

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Experts

2 / 17 results