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research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations , June 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

research The genetics of androgenetic alopecia

50 citations , March 2001 in “Clinics in Dermatology”

Genes and hormones cause hair loss, with four genes contributing equally.

research The slick hair coat locus maps to chromosome 20 in Senepol-derived cattle

51 citations , January 2007 in “Animal Genetics”

This study identified the location of the genetic locus for the slick hair coat trait in cattle on bovine chromosome 20, which may contribute to heat tolerance.

research Chromosomal Localization of Mouse Hair Keratin Genes^a

21 citations , December 1991 in “Annals of the New York Academy of Sciences”

This study suggests that hair keratin gene mutations in mice may be linked to specific loci on chromosomes 11 and 15, potentially influencing keratin expression or structure.

research Marie Unna Hereditary Hypotrichosis Gene Maps to Human Chromosome 8p21 Near Hairless

4 citations , March 2000 in “Journal of Investigative Dermatology”

The gene for Marie Unna hereditary hypotrichosis is located on chromosome 8p21, near the hairless gene.

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community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

140 upvotes 11 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community Genomic Sequencing for Hair Loss

in Research/Science 156 upvotes 5 months ago

Hair loss treatments like Minoxidil, finasteride, and potential mRNA therapies are discussed. There is skepticism about targeting specific genes due to the complex genetic nature of hair loss.

community Chromosome 20’s balding effects and why fin likely isn’t working for some.

in Treatment 96 upvotes 1 year ago

Finasteride is effective for DHT/AR-driven hair loss but not for chromosome 20-driven cases, where treatments like minoxidil, prostaglandin analogs, and low-level laser therapy may be more beneficial. Genetic testing can help determine the underlying cause of hair loss to tailor treatment effectively.

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