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research From skin microrelief to wrinkles. An area ripe for investigation

108 citations , January 2003 in “Journal of Cosmetic Dermatology”

This summary explains the different types of wrinkles, their causes, and their distinct microanatomical characteristics, noting that each type may respond differently to treatments.

research The riddle of genuine skin microrelief and wrinkles

52 citations , November 2006 in “International Journal of Cosmetic Science”

This review discusses the identification and classification of different wrinkle types based on histological features and microanatomy, emphasizing their varying responses to treatments, and reports no new clinical results.

A Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Effects of a Polyphenol-Rich Fruit Extract Combined with Biotin on Wrinkle Morphology, Skin Surface Roughness, and Hair Shedding

research A Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Effects of a Polyphenol-Rich Fruit Extract Combined with Biotin on Wrinkle Morphology, Skin Surface Roughness, and Hair Shedding

June 2026 in “Cosmetics”

In this study, a polyphenol and biotin supplement improved skin roughness and significantly reduced hair shedding, but did not demonstrate clear superiority over placebo in overall skin outcomes.

Cloning of Wrinkle-Free, a Previously Uncharacterized Mouse Mutation, Reveals Crucial Roles for Fatty Acid Transport Protein 4 in Skin and Hair Development

research Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development

93 citations , April 2003 in “Proceedings of the National Academy of Sciences of the United States of America”

This study identified an unexpected critical role for the FATP4 protein in skin and hair development in mice, linking it to a potential candidate gene for restrictive dermopathy in humans.

research Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function

74 citations , June 2018 in “Cell death and disease”

In this study, researchers found that depleting mtDNA in mice caused skin wrinkles and hair loss but restoring mitochondrial function reversed these effects, highlighting mtDNA's significant role in skin and hair health.

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Community Join

5 / 224 results

community How legit is the skin issues (loss of collagen, wrinkles, under eye cricles etc) with minoxodil?

7 upvotes 8 years ago

Minoxidil may cause facial bloat, wrinkles, and dark circles, with some users experiencing these side effects quickly. Finasteride can cause painful ejaculations and watery semen, but concerns about penis shrinkage are generally unfounded.

community Minoxidil actually reduces wrinkles

in Research/Science 209 upvotes 1 year ago

Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.

community How to treat skin when using minoxidil?

6 upvotes 5 years ago

Minoxidil may cause skin issues like wrinkles and dark undereyes, possibly due to alcohol content. Alternatives include collagen supplements, vitamin C, and skincare products; some users prefer finasteride for hair loss without these side effects.

community Haircafe - TOPICAL minoxidil is an anti aging drug

in Minoxidil 245 upvotes 1 year ago

Topical minoxidil may cause skin aging effects like wrinkles and dark circles, possibly due to its alcohol content, while oral finasteride is reported to make users look younger. Switching to oral minoxidil or using moisturizers might help reduce these skin issues.

community Elastin based peptides help reduce wrinkles. Can they help the scalp too?

14 upvotes 5 months ago

Elastin-based peptides may help reduce wrinkles and could potentially benefit the scalp. The conversation suggests using them with hyaluronic acid gel to improve scalp health and reduce hair fall.

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Learn

2 / 801 results

learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Tretinoin

the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

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Experts

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Clinics

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All 13 clinic results →