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research Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes

13 citations , November 2013 in “Journal of Endocrinology/Journal of endocrinology”

This study found that the vitamin D receptor, but not its ligand, regulates genes involved in hair cycle progression, suggesting a role in integrating hormone signaling pathways for hair and epidermal functions.

research Roles of jumonji and jumonji family genes in chromatin regulation and development

178 citations , May 2006 in “Developmental Dynamics”

This review discusses the role of jumonji family proteins in chromatin regulation and development, highlighting their involvement in transcriptional repression and histone demethylation, but reports no new experimental findings.

research To be hairless or wise?

November 2005 in “Nature Reviews Molecular Cell Biology”

In this study, researchers discovered that the interaction between the hairless protein and the wise protein is crucial for hair-follicle regeneration, helping bald mice regrow fur.

research Hairless triggers reactivation of hair growth by promoting Wnt signaling

137 citations , September 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

In this study, researchers found that transgenic expression of the Hairless gene in keratinocytes can restore hair follicle regeneration in Hr-deficient mice by repressing Wise, a modulator of Wnt signaling.

research Hairless: A nuclear receptor corepressor essential for skin function

January 2006 in “Advances in developmental biology”

This review discusses the roles of the hairless (HR) protein as a corepressor, particularly its impact on RORα-mediated transcriptional repression, and reports no new experimental findings.

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Community Join

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community PSA: Not all Finasteride generics are created equal, effectiveness and severity of side-effects can vary by manufacturer.

1 year ago

Switching generic finasteride manufacturers can reduce side effects while maintaining effectiveness. Different fillers in generics may affect bioavailability and cause varying side effects.

community Mature hairlines in general and defining them

13 upvotes 5 years ago

A "mature hairline" is subjective and may not indicate future stability. Finasteride and minoxidil are suggested treatments for hair loss.

community Why is the general consensus that if you can’t tolerate 5AR Inhibitors you’re “cooked”?

in Research/Science 15 upvotes 11 months ago

Alternatives to finasteride for hair loss include minoxidil, alfatrodial, fluridil, pyrilutamide, and Nizoral. These treatments may not be as effective as finasteride but can help slow hair loss progression.

community Does someone like Prince William have such intense balding genetics that not even Dutasteride can save them?

in Chat 113 upvotes 1 year ago

Some men have strong balding genetics that treatments like Dutasteride, Minoxidil, or Finasteride may not fully address. Early intervention is believed to help, but many accept hair loss without treatment.

community The first and third are from October 3rd, 2024. 2nd and 4th pics are from today (February 20th 2024) the 5th pic is just a general overall shot of how it looks. (4 month progress)

54 upvotes 1 year ago

The user experienced significant hair regrowth using minoxidil (5% topical) once nightly and finasteride (1mg) daily, despite a poor diet, high stress, and lack of sleep. They plan to start dermastamping and improve their overall health for better results.

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learn Neem Oil

Oil from the neem tree, used in traditional remedies

Clinics

5 / 9 results

Experts

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