October 2025 in “Saúde (Santa Maria)” This review reported that spironolactone, used off-label, is an effective and safe treatment option for adult women with acne, presenting fewer adverse reactions compared to common treatments like antimicrobials, which carry the risk of microbial resistance.
December 2022 in “Zenodo (CERN European Organization for Nuclear Research)” In this integrative literature review, the researchers reported that finasteride appears highly effective for treating androgenetic alopecia and acne, showing notable benefits after brief treatment durations, though careful dose management is required due to potential sexual side effects.
41 citations
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June 2010 in “Anais Brasileiros de Dermatologia” This study found that isotretinoin is a safe and well-tolerated acne treatment, with common adverse effects like cheilitis manageable through symptomatic medication and no significant changes in lipid or liver enzyme levels.
December 2019 in “RIUnB Institutional Repository (University of Brasília)” This study developed two types of polymeric nanoparticles containing clindamycin phosphate for potential topical acne treatment and found that the NP-AH-CDM-4 formulation preferentially penetrated hair follicles even with sebaceous obstruction, suggesting its promise for more effective acne therapy without causing skin irritation.
2 citations
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July 2021 in “Annales De Dermatologie Et De Venereologie” In this study, isotretinoin provided complete remission in some patients with vulvar Fordyce adenitis, a condition causing painful recurrent lesions on the labia minora and inner labia majora.
