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research Biocompatible nanoparticles and vesicular systems in transdermal drug delivery for various skin diseases

151 citations , November 2018 in “International Journal of Pharmaceutics”

This review discusses various nanoparticles and nanoemulsions being investigated for transdermal drug delivery and reports no clinical results; it highlights potential applications in treating alopecia, wound healing, psoriasis, and melanoma.

research In Vitro Percutaneous Permeation and Skin Accumulation of Finasteride Using Vesicular Ethosomal Carriers

84 citations , July 2008 in “Aaps Pharmscitech”

Ethosomes improve finasteride delivery through skin for hair loss treatment.

research Niosomes as a vesicular carrier for topical administration of minoxidil: formulation and in vitro assessment

48 citations , December 2013 in “Drug Delivery and Translational Research”

This study found that minoxidil-loaded niosomes with a Span 60 and cholesterol ratio of 1:2 significantly increased skin retention of minoxidil compared to control gel.

Gelatin-Chondroitin-6-Sulfate-Hyaluronic Acid Scaffold Seeded with Vascular Endothelial Growth Factor 165 Modified Hair Follicle Stem Cells as a Three-Dimensional Skin Substitute

research Gelatin-chondroitin-6-sulfate-hyaluronic acid scaffold seeded with vascular endothelial growth factor 165 modified hair follicle stem cells as a three-dimensional skin substitute

45 citations , October 2014 in “Stem cell research & therapy”

This study found that using 3D Gel-C6S-HA scaffolds seeded with VEGF165-modified rat hair follicle stem cells enhanced angiogenesis and vascularization in tissue-engineered skin, improving wound healing.

research Iontophoretic Transdermal Delivery of Finasteride in Vesicular Invasomal Carriers

15 citations , February 2013 in “Pharmaceutical nanotechnology”

This study found that invasomes enhanced the iontophoretic transdermal delivery of finasteride in rabbits, increasing AUC and T1/2 compared to oral suspension.

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learn Vascular Endothelial Growth Factor

What is Vascular Endothelial Growth Factor (VEGF), and how does it support hair growth in alopecia? VEGF promotes hair growth by enhancing blood supply to hair follicles.
Can products that stimulate Vascular Endothelial Growth Factor (VEGF) improve blood flow to hair follicles? Yes, products that stimulate VEGF may improve blood flow to hair follicles.
Is Vascular Endothelial Growth Factor (VEGF) available as a topical treatment, or is it only stimulated indirectly? VEGF is not available as a topical treatment for hair loss.
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community Cold and Japanese researchers. The Japanese began to suspect something. But they understood the mechanism to some extent. ( Cold shock therapy promotes hair growth in association with upregulation of cold-inducible RNA-binding protein and vascular endothelial growth factor).

36 upvotes 1 year ago

Cold shock therapy may promote hair growth, but cold alone is not effective. Combining treatments like minoxidil, finasteride, cold showers, spicy foods, and exercise may enhance results.

community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

in Finasteride/Dutasteride 41 upvotes 2 years ago

Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.

community My 6 month journey thus far... 47yo Male.

421 upvotes 10 months ago

A 47-year-old male experienced significant hair regrowth over six months using 1mg oral finasteride, 5mg oral minoxidil, and 1ml 5% topical minoxidil, along with weekly derm stamping. He reported no major side effects, improved prostate health, and increased vascularity, with hair texture changes and minor nasal congestion.

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