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This article provides an overview of diagnosing Cushing's syndrome, emphasizing the importance of assessing clinical signs and the appropriate use of first-line biochemical screening.

This case report details a 13-year-old boy with Cushing syndrome, where BIPSS identified the pituitary gland as the cortisol excess source and hormonal tests showed suppressed puberty markers.

In this study, a 37-year-old female with resistant hypertension and signs of Cushing's syndrome and primary aldosteronism was found to have normal cortisol levels but high levels of cortisol and aldosterone via adrenal venous sampling, leading to a diagnosis confirmed by right adrenalectomy.

This study found a high prevalence of hyperandrogenemia in women with PCOS, with distinct biochemical differences according to BMI and presence of hyperandrogenemia.

This case report describes a testosterone- and cortisol-secreting adrenocortical oncocytoma causing hirsutism in a 23-year-old woman, highlighting adrenal oncocytomas as an important consideration for differential diagnosis.