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research Interaction of Minoxidil with Pigment in Cells of the Hair Follicle: An Example of Binding without Apparent Biological Effects

7 citations , January 1992 in “Skin Pharmacology and Physiology”

This study found that minoxidil accumulated in pigmented hair follicle cells more than in unpigmented ones, but this targeting by pigmentation did not affect hair growth.

research Towards a “free radical theory of graying”: melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage

210 citations , May 2006 in “The FASEB journal”

This study found that oxidative stress in hair follicle melanocytes contributes to premature aging and apoptosis, providing insights into graying as a model for studying aging and testing antiaging therapies.

research Untersuchungen der Fremdstoffbindung in permanenten Keratinozyten- und Melanozyten-Zelllinien sowie die Eignung von Primärkulturen aus humanen Haarfollikeln zur In-vitro-Messung der Fremdstoffaufnahme im Haar

January 2006 in “Carl von Ossiezky University of Oldenburg”

This study observed that unpigmented keratinocytes saturate quickly with foreign substance uptake compared to pigmented melanocytes, where melanin significantly enhances binding.

research Fibroblast Growth Factor Influences the Development and Cycling of Murine Hair Follicles

58 citations , April 1993 in “Developmental Biology”

This study found that subcutaneous injections of basic fibroblast growth factor in neonatal mice delayed the development and hair growth cycles of hair follicles compared to controls.

research Regenerating Hair Follicles

May 2007 in “Science's STKE”

This study found that modulating Wnt signaling can promote new hair follicle regeneration in adult mouse skin wounds, suggesting potential treatment strategies for scarring and alopecia.

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community Stopped on fin, diffuse thinner, white hairs meaning

in Finasteride/Dutasteride 5 upvotes 1 month ago

The user stopped using finasteride and noticed diffuse thinning and white hairs on the crown, considering restarting finasteride and adding minoxidil. White hairs are miniaturized follicles that may regain pigment and thickness with treatment, and it's suggested to wait 12 months before considering a hair transplant.

community Still have itchy scalp after 6 months on fin + keto

29 upvotes 4 months ago

The user experiences an itchy scalp despite using finasteride and ketoconazole shampoo for hair loss. Suggestions include trying different shampoos, switching to dutasteride, and using topical treatments for inflammation.

community Prevention of age-related beard graying in humans by the topical application of Eriodictyon angustifolium extract

5 upvotes 4 years ago

Topical application of Eriodictyon angustifolium extract can prevent and reverse age-related beard graying and darken gray hair by increasing melanin production. Sterubin, a component of the extract, also promotes hair pigmentation and protects cells from DNA damage.

community What is this pigmentation around my follicles?

in Chat 29 upvotes 1 year ago

The conversation discusses potential causes of pigmentation around hair follicles, suggesting sebum buildup, autoimmune conditions, or dermatitis. Treatments mentioned include finasteride, dutasteride, and an anti-inflammatory diet, with a recommendation to consult a doctor for a proper diagnosis.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

7 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

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