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community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 194 upvotes 1 year ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

community Gut microbiome imbalances linked to scalp inflammation and hair follicle impact

in Technology 243 upvotes 4 months ago

Gut microbiome imbalances can cause scalp inflammation and affect hair follicles, potentially leading to hair loss. Treatments include finasteride, peptides like BPC-157, TB-500, KPV, and lifestyle changes such as diet and exercise.

Research

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research In-vivo uptake and metabolism of testosterone by the skin and other tissues of the rat

8 citations , May 1982 in “Journal of Endocrinology/Journal of endocrinology”

This study suggests that in rat skin, testosterone itself may play a more significant role in androgen action than 5α-dihydrotestosterone, unlike in the prostate where 5α-DHT is more dominant.

research 6 Peripheral androgens and the role of androstanediol glucuronide

57 citations , May 1986 in “Clinics in endocrinology and metabolism”

This review found that women with idiopathic hirsutism may have increased 5α-reductase activity, as indicated by elevated levels of a dihydrotestosterone-reduced metabolite, but more research is needed to confirm its clinical relevance as a biomarker.

research Diagnosis of hyperandrogenism: Biochemical criteria

77 citations , June 2006 in “Best Practice & Research Clinical Endocrinology & Metabolism”

This review discusses the importance of androgen production and metabolism in hyperandrogenism, the use of specific serum markers for diagnosis, and the need for improved assays for clinical testing, but reports no new results.

research Idiopathic Hirsutism*

47 citations , August 2000 in “Endocrine Reviews”

This review discusses idiopathic hirsutism, potential underlying mechanisms, and various therapeutic approaches without providing new clinical results, and emphasizes the need for further research on well-defined patient groups.

research Plasma androsterone/epiandrosterone sulfates as markers of 5α-reductase activity: Effect of finasteride in normal men

13 citations , August 1997 in “Steroids”

Finasteride effectively lowers specific hormone levels, helping monitor treatment progress.

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