This study suggests that topical application of a hydrogel containing magnetized saline water may promote wound healing in stage 2-3 pressure ulcers in elderly patients by stimulating autophagy, based on observed clinical improvements in a case series.
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October 2023 in “Advanced Drug Delivery Reviews” This review highlights that unresolved inflammation is a major issue in diabetic foot ulcers and discusses emerging biomaterials-based strategies to modulate the inflammatory response, potentially aiding in tissue regeneration and healing in these chronic wounds.
June 2026 in “University of Science and Technology Journal for Medical Sciences” In this study, both platelet-rich plasma gel and 1% phenytoin cream showed comparable results for wound healing in diabetic foot ulcers in rats, with PRP providing slightly advanced histological improvements; however, the differences were not statistically significant.
April 2023 in “Journal of Investigative Dermatology” This study found that treprostinil, a prostacyclin analog, significantly delayed fibroblast migration from healthy donors but did not affect fibroblast migration derived from diabetic foot ulcers.
November 2024 in “Journal of Investigative Dermatology” This study identified PTEN as a key regulator in non-healing venous leg ulcers, suppressing immune responses and lymphangiogenesis, suggesting its potential as a therapeutic target for promoting VLU healing.