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DDB1 and CUL4 associated factor 17

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Co-Expression Pattern of Artemis Serine 516 Phosphorylation with Indicators in Differentiation, Proliferation, and Apoptosis of Human Anagen Hair Follicles: An Immunofluorescence Double-Staining Study

research Co-Expression Pattern of Artemis Serine 516 Phosphorylation with Indicators in Differentiation, Proliferation, and Apoptosis of Human Anagen Hair Follicles: An Immunofluorescence Double-Staining Study

January 2023 in “Frontiers in bioscience”

Artemis protein may help control hair growth and health by influencing cell processes.

research Hair And Nails: A Review Of Recent Studies

May 2009 in “Medical and surgical dermatology/Medical & surgical dermatology”

Hair and nail conditions can stabilize or improve over time, and new treatments show promise.

research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis

242 citations, February 2016 in “Science”

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

research Protein Degradation: Expanding the Toolbox to Restrain Cancer Drug Resistance

7 citations, January 2023 in “Journal of Hematology & Oncology”

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

research Recent Progress in the Effect of Ferroptosis of Hepatic Stellate Cells on the Development of Liver Fibrosis

2 citations, September 2023 in “Frontiers in molecular biosciences”

Inducing ferroptosis in hepatic stellate cells is crucial for treating liver fibrosis.

View more "ubiquitin-dependent proteolysis" in research →

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community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

HMI115_GIGACHAD in Research/Science 126 upvotes 1 year ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

Synizs in Research/Science 134 upvotes 9 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.