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4 / 4 resultslearn Dutasteride
Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity
learn Finasteride
Frontline, gold standard treatment for combatting androgenic alopecia
learn Metformin
diabetes drug with anti-inflammatory, immunomodulatory, and insulin-sensitizing properties
Research
5 / 1000+ results![The extract of Thujae occidentalis semen inhibited 5α-reductase and androchronogenetic alopecia of B6CBAF1/j hybrid mouse](/images/research/b2337b85-3aec-47c3-ad0b-222580eca264/small/28158.jpg)
research The extract of Thujae occidentalis semen inhibited 5α-reductase and androchronogenetic alopecia of B6CBAF1/j hybrid mouse
Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.
![A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization](/images/research/fc1e5c31-4c72-4baf-bc97-b963d6e20160/small/31745.jpg)
research A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization
The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.
![A Role for Steroid 5 alpha-reductase 1 in Vascular Remodelling During Endometrial Decidualisation](/images/research/f52ab12a-ca9a-4c96-b105-312119fb5672/small/31753.jpg)
research A Role for Steroid 5 alpha-reductase 1 in Vascular Remodelling During Endometrial Decidualisation
The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.
![Four-amino acid segment in steroid 5 alpha-reductase 1 confers sensitivity to finasteride, a competitive inhibitor.](/images/research/0cbb0e81-3fd6-46bb-b245-a382219c25c4/small/1982.jpg)
research Four-amino acid segment in steroid 5 alpha-reductase 1 confers sensitivity to finasteride, a competitive inhibitor.
Four-amino acid part makes enzyme sensitive to finasteride.
![Selective non-steroidal inhibitors of 5α-reductase type 1](/images/research/a5e4b579-dcaf-44af-ac22-a1392f115f7b/small/28705.jpg)
research Selective non-steroidal inhibitors of 5α-reductase type 1
Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.
Community Join
5 / 995 resultscommunity What About Phytosterol Alternatives - Rice Bran Oil - Natural DHT Blockers
The conversation discusses natural DHT blockers like rice bran oil, which may reduce 5α-reductase activity similarly to Minoxidil and Dutasteride. One user argues that finasteride is more reliable and effective than natural alternatives.
community FCE 28260: A Forgotten 5α-Reductase Inhibition
FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
community Finasteride only reduces scalp DHT by ~40%. Why does it work?
How Finasteride and Dutasteride help reduce hair loss by reducing the amount of DHT in scalp areas, as well as discussing factors such as sensitivity to DHT, 5α-reductase expression in different parts of the hair follicle, and scalp tension.
community Trying to understand finasteride side effects and post finasteride syndrome
The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.
community Detailed 6 months update for FUE HT and 4 years of FIN-MIN journey
A 25-year-old who has been using minoxidil and finasteride for 4 years to treat hair loss, underwent a successful FUE hair transplant in Mumbai, India, in April 2023. The user reported positive results, including increased hair density and reduced frizziness, and plans to continue treatment for further growth.