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    Research 10 of 1000+

    1. Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men. The Journal of Clinical Endocrinology and Metabolism · 1996 · 6 citations
    2. LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1. Proceedings of the National Academy of Sciences of the United States of America · 1993 · 53 citations
    3. Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men The Journal of Clinical Endocrinology and Metabolism · 1996 · 7 citations
    4. Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens Journal of Medicinal Chemistry · 1995 · 12 citations
    5. Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, <i>In Vitro</i>, and <i>In Silico</i> Studies ACS Omega · 2025
    6. Selective non-steroidal inhibitors of 5α-reductase type 1 2004 · 49 citations
    7. Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, <i>InVitro</i>, and <i>In Silico</i> Studies OPAL (Open@LaTrobe) (La Trobe University) · 2025
    8. In silico screening of effective inhibitor of 5α-reductase type 1 for androgenic alopecia treatment Natural Product Research · 2021 · 1 citations
    9. Predominant expression of 5 alpha-reductase type 1 in pubic skin from normal subjects and hirsute patients. 1996 · 11 citations
    10. Design, synthesis and biological evaluation of novel androst-3,5-diene-3-carboxylic acid derivatives as inhibitors of 5α-reductase type 1 and 2 Steroids · 2017 · 8 citations
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    Community 10 of 84

    1. How come Dut doesn’t cause more brain problems than fin if it inhibits Type 1 5AR? Reddit · 26 Jun 2024
    2. 5ar Type I in the frontal hair follicles - Dutasteride Reddit · 30 Apr 2024
    3. Thoughts on this Article: Post-Finasteride and Neurological Effects Reddit · 16 Mar 2024
    4. The truth about Dutasteride (w/ sources) Reddit · 24 Jan 2023
    5. DHT and 5AR respect post, it's importance within the brain Reddit · 3 Mar 2024
    6. 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that? Reddit · 3 Oct 2024
    7. Was scared to try fin and jumped straight to 2.5mg Dut? Reddit · 12 Sept 2026
    8. Whats up with all the dutasteride destroying hair posts Reddit · 12 May 2023
    9. My story (22m, fin, min, niz, RU, dut –> part frontal hair system) Reddit · 6 May 2023
    10. Peptides that Stop Hair Loss? | In-depth Literature Review Video Reddit · 6 Jul 2024
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    Learn 3 of 6

    1. Finasteride Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically
    2. Dutasteride 5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride
    3. Neem Oil Oil from the neem tree, used in traditional remedies
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