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This study observed in mouse skin that trichohyalin granules in hair follicles transform into filamentous structures as inner root sheath cells differentiate and cornify.

This review discusses the roles of filaggrin and trichohyalin in keratinocyte differentiation and reports no new results; the authors introduce possible hybrid granules in tongue epithelia.

This study found that trichohyalin is expressed in various normal and pathological epithelia beyond hair follicle cells, where it is uniquely associated with filaggrin, suggesting a specific role in aggregating K6/K16-containing intermediate filaments.

The researchers reported that scaffoldin, a protein identified in chicken embryos, likely plays a role in forming periderm granules and contributes to the soft cornification of embryonic epidermis.

This study analyzes the fine structure and protein distribution in monotreme hairs, finding similarities with other mammals and detailing unique immunocytochemical features in their inner root sheaths.