research CD4+ Treg expansion arrests disease progression in a pre-clinical model of alopecia areata
In this study, treatment with IL-2C to expand Tregs effectively halted hair loss progression in a murine model of alopecia areata.
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5 / 846 resultsresearch 039 Expansion of regulatory T Cells restrains pathogenic CD8 T Cells in a murine model of alopecia areata
Expanding regulatory T cells may help treat alopecia areata by reducing harmful immune cells.
research Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels
This study found that deleting Stim1 and Stim2 in mature T regulatory cells disrupts Ca 2+ signaling, preventing their differentiation and leading to severe autoimmune disorders in mice.
research Regulatory T cells: master orchestrators of immune tolerance and tissue homeostasis
This review examines the potential of regulatory T cell-based therapies to transform treatment across various medical specialties by promoting immune tolerance and tissue repair, but it reports no new clinical results.
research Regulatory T cell dysfunction and immunotherapeutic breakthroughs in type 1 diabetes
This review discusses the impaired functionality of regulatory T cells in the pancreas during the development of Type 1 diabetes, highlighting their role in disease pathogenesis, potential of Treg-based therapies, and challenges in clinical applications.
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