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Research

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Cross-Sex Hormone Therapy in Trans Persons Is Safe and Effective at Short-Term Follow-Up: Results from the European Network for the Investigation of Gender Incongruence

research Cross‐Sex Hormone Therapy in Trans Persons Is Safe and Effective at Short‐Time Follow‐Up: Results from the European Network for the Investigation of Gender Incongruence

204 citations , May 2014 in “The Journal of Sexual Medicine”

This study concluded that current cross-sex hormone treatments for trans men and trans women are effective with a low risk of side effects in the short term, though they did observe specific clinical changes.

research SUN-144 Initiating Estradiol Hormone Therapy in a Transgender Woman With Multifocal Idiopathic Localization-Related Epilepsy

October 2025 in “Journal of the Endocrine Society”

In this case report, a transgender woman with refractory epilepsy began estrogen therapy for gender-affirming purposes, experiencing stable epilepsy and reduced gender dysphoria through ongoing multidisciplinary care, highlighting the importance of careful management for similar patients.

research Canine Alopecia Secondary to Human Topical Hormone Replacement Therapy in Six Dogs

14 citations , February 2015 in “Journal of the American Animal Hospital Association”

This study reports that transdermal exposure to owners' topical hormone replacement therapy caused alopecia in six dogs, but the condition resolved after the therapy was discontinued.

research The role of androgens in hormone replacement therapy

6 citations , September 2005 in “Expert Opinion on Pharmacotherapy”

This review discusses the role of androgens in women's sexual health and highlights the need for further research on androgen replacement therapy to optimize quality of life, but reports no new clinical results.

research Microneedles-A new paradigm in transdermal delivery of therapeutic agents

1 citations , January 2022 in “Pharmaceutical Sciences Asia”

This review highlights the potential of microneedles as a low-cost, well-tolerated method for transdermal drug delivery in dermatology, though further research is needed to establish their clinical efficacy.

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Community Join

5 / 28 results

community I think this is my stop, gentlepeople. So long and thanks for all the data 👋

2264 upvotes 1 year ago

A user shared their successful experience with hair regrowth and transitioning from male to female using minoxidil, finasteride, Nutrafol, microneedling, and hormone replacement therapy (HRT). They expressed gratitude for the results and encouraged others to explore treatments that align with their personal goals.

community My Idea for a possible new hairloss treatment

53 upvotes 6 years ago

Exploring a potential hair loss treatment using the enzyme AKR1C2 to locally reduce DHT levels. Challenges include enzyme delivery through the skin and high production costs, with gene therapy or stem cells suggested as future alternatives.

community What do you guys think about this thread on Twitter / X ?

1 year ago

Hair loss is linked to factors like chronic tension and inflammation, not just DHT, and solutions include natural light exposure and scalp health improvement. Finasteride is debated, with some users experiencing side effects like ED, while others find it effective for hair regrowth.

community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction

in Research/Science 36 upvotes 2 months ago

Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.

community Progressive insomnia (treatment-resistant) due to Finasteride

8 upvotes 4 years ago

A medical student experienced hair loss slowing with Finasteride but developed severe, treatment-resistant insomnia. They tried various medications with little effect, suspecting Post-Finasteride Syndrome, and others suggested the insomnia might be linked to Finasteride's impact on neurosteroids.

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Clinics

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Learn

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learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

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