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research Estradiol‐induced alopecia in five dogs after contact with a transdermal gel used for the treatment of postmenopausal symptoms in women

10 citations , July 2015 in “Veterinary Dermatology”

This study found that noninflammatory alopecia in dogs can be caused by exposure to estradiol gel used by their owners for postmenopausal symptoms, with hair regrowth observed after minimizing exposure.

research Sex hormones and related compounds, including hormonal contraceptives

January 2014 in “Side effects of drugs annual”

This review discusses the 2011 publications on the side effects of sex hormones and related compounds, without reporting new clinical results.

Original Research—Endocrinology: Comparison of the Steady-State Pharmacokinetics, Metabolism, and Variability of a Transdermal Testosterone Patch Versus a Transdermal Testosterone Gel in Hypogonadal Men

research ORIGINAL RESEARCH—ENDOCRINOLOGY: Comparison of the Steady‐State Pharmacokinetics, Metabolism, and Variability of a Transdermal Testosterone Patch Versus a Transdermal Testosterone Gel in Hypogonadal Men

38 citations , February 2005 in “The journal of sexual medicine”

This study found that a testosterone patch and gel showed bioequivalent testosterone levels in hypogonadal men, but the patch mimicked a natural circadian profile, while the gel resulted in higher dihydrotestosterone levels.

research The Effects of Transdermal Dihydrotestosterone in the Aging Male: A Prospective, Randomized, Double Blind Study

110 citations , April 2002 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.

research Iontophoretic Transdermal Delivery of Finasteride in Vesicular Invasomal Carriers

15 citations , February 2013 in “Pharmaceutical nanotechnology”

This study found that invasomes enhanced the iontophoretic transdermal delivery of finasteride in rabbits, increasing AUC and T1/2 compared to oral suspension.

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Community Join

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community I think this is my stop, gentlepeople. So long and thanks for all the data 👋

2264 upvotes 1 year ago

A user shared their successful experience with hair regrowth and transitioning from male to female using minoxidil, finasteride, Nutrafol, microneedling, and hormone replacement therapy (HRT). They expressed gratitude for the results and encouraged others to explore treatments that align with their personal goals.

community Using the nuclear stack and still losing hair... Is this the end for my hair?

4 upvotes 3 years ago

The user is experiencing ongoing hair loss despite using a comprehensive treatment regimen including dutasteride, oral minoxidil, cyproterone acetate, transdermal estradiol, and topical bicalutamide. They suspect cyproterone acetate may be worsening their hair loss and are considering switching to injection monotherapy.

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Learn

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learn Ethynylestradiol

learn Ethinylestradiol

learn Alfatradiol

a synthetic estrogen used topically as an anti-androgen

learn Estradiol

an estrogen promoting hair regrowth more commonly used in women

How does topical Estradiol compare to oral Estradiol in treating alopecia? Topical estradiol delivers hormone to the scalp with less systemic exposure, but evidence is thin and it is still a hormone. It needs a doctor's supervision, and people with estrogen-sensitive cancers must not use it without medical approval.
Is applying Estradiol directly to the scalp effective for hormone-related hair thinning? Applying Estradiol directly to the scalp may help with hormone-related hair thinning.
Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol helps treat hair loss by balancing hormones and supporting hair follicle health.

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Experts

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David Gellei
Melbourne, VIC, Australia

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David Gellei