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research Meeting Report: 68th Montagna Symposium on the Biology of Skin “Decoding Complex Skin Diseases: Integrating Genetics, Genomics, and Disease Biology”

June 2020 in “Journal of Investigative Dermatology”

This symposium reviewed advances in understanding complex skin diseases through genetics and genomics, emphasizing the role of regulatory signals and environmental components in disease development, but reports no new clinical findings.

research Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles

4 citations , November 2020 in “BMC Dermatology”

This study identified 374 eQTLs in scalp hair follicles associated with genes involved in metabolic, mitotic, immune processes, and responses to steroid hormones, contributing insights into genetic variation and hair traits.

research Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations

58 citations , June 2018 in “Scientific reports”

This study identified novel genetic associations with skin phenotypes such as age-spots, freckles, and hair characteristics in Japanese women, providing insights into the genetic basis of these traits.

research Identifying causal genes in alopecia areata using integrative analysis of differential expression and Mendelian randomization

July 2024

This study identified four genes related to alopecia areata: GIMAP6 and ALOX15 as risk factors, and GALNT6 and HEG1 as protective factors, noting significant validation differences in GALNT6 and HEG1.

research DNA Methylation‐Regulated ZDHHC17 Promotes the Risk of Facial Skin Aging

December 2025 in “Clinical Cosmetic and Investigational Dermatology”

This study highlights the potential of ZDHHC17 methylation as a biomarker or therapeutic target in addressing skin aging, offering new insights into its molecular mechanisms.

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community Trans guy with frontal hair loss - making sure I'm doing the right things.

5 upvotes 8 years ago

A trans man experiencing frontal hair loss is considering using finasteride and minoxidil, while also consulting a dermatologist. He is cautious about starting treatments before his appointment and is concerned about the effects of rapid weight loss on his hair.

community 2022->2026, 3.5 years Fin, no min, trans male

81 upvotes 2 months ago

A trans male shared his 3.5-year experience using finasteride for hair loss, noting improvements in hair density and hairline thickness without using minoxidil due to health concerns. He also uses Tołpa Torf shampoos and scalp serums, and emphasizes the importance of mental health and self-image in his journey.

community Concerns About Hair Loss and Treatment Options for a Trans Woman

in Transgender 127 upvotes 1 year ago

A trans woman is experiencing hair loss and is considering treatments like cyproterone, dutasteride, and oral minoxidil. She is concerned about potential hair growth on her face, chest, or legs due to minoxidil.

community 19yo Trans Man MPB Fin 1mg little over 2 months. Regrowth or just getting worse. never been this bad before lol

in Journals / Progress Pictures 110 upvotes 1 year ago

A 19-year-old trans man has been using Finasteride 1mg for a little over two months and is concerned about worsening hair loss, noting a fuzzy and soft hairline and crown. The user is upset as the hair loss appears worse than before starting the treatment.

community 23-Year-Old Trans Male: Concerns About Minox and Finasteride for Hair Loss

in General 298 upvotes 1 year ago

A 23-year-old trans male is concerned about hair loss and is considering treatments like topical and oral minoxidil and finasteride. They are worried about the effects on their pet and hormone balance and are seeking affordable options within their existing medical team.

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Learn

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learn Alfatradiol

Does Alfatradiol work the same for women, men, and trans people? Almost all controlled data on topical alfatradiol comes from cisgender women, where hair density and thickness stayed nearly unchanged over 6 months while minoxidil improved them (the trial had no placebo group). No published controlled trial covers cisgender men, and none covers trans people at all — so the honest answer is that the difference has not been measured.

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