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In this case report, researchers documented a rare instance of trans-epidermal elimination of insulin formulation in a 45-year-old woman with diabetes, suggesting that insulin or its excipients may have caused a granulomatous reaction leading to skin lesions at injection sites and impaired diabetes control.

In this case study, a 62-year-old male with a history of uncontrolled diabetes and chronic kidney disease was diagnosed with perforating folliculitis after presenting with dark, raised, pruritic lesions on his limbs, confirmed by histopathological examination showing collagen extruding into hair follicles.

This research found that Foxc1 transcription factor and COL17A1 are critical in regulating quiescence and hair thinning in hair follicle stem cells, with aging-related DNA damage leading to hair loss.

The study found that aging in hair follicle stem cells leads to hair follicle miniaturization and eventual hair loss in both wild-type mice and humans by proteolyzing type XVII collagen.

Acquired perforating dermatosis often affects skin in people with kidney issues and diabetes.