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research Theoretical investigation of the conformational space of baicalin

3 citations , July 2017 in “Journal of Molecular Graphics & Modelling”

This study analyzed the geometric and electronic properties of baicalin conformers, finding that BCLa2TT and BCLa1TT conformers exhibit high stability in aqueous solutions and are favorable for interactions with positively charged species.

Mechanisms of Disease: Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 as a Novel Treatment for Metabolic Syndrome

research Mechanisms of Disease: selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome

69 citations , December 2005 in “Nature Clinical Practice Endocrinology & Metabolism”

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

research Experimental and Clinical Pharmacology ofZiziphus jujubaMills

31 citations , January 2017 in “Phytotherapy Research”

This review reports on the traditional and ethnopharmacological uses of Ziziphus jujuba Mills, noting its increasing global popularity for treating various ailments, but highlights that its acceptance into the European Pharmacopoeia remains unresolved due to scientific and regulatory challenges.

The Extract of Periplaneta Americana Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota

research The Extract of Periplaneta americana (L.) Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota

August 2025 in “Current Issues in Molecular Biology”

This study demonstrated that Periplaneta americana extract significantly promoted hair regeneration in depilated mice by enhancing superoxide dismutase activity, upregulating vascular endothelial growth factor, modulating the FOXO/PI3K/AKT pathway, and restoring skin microbiome balance, suggesting its potential as a novel therapeutic candidate for alopecia.

research Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review

70 citations , September 2017 in “Expert opinion on therapeutic patents”

This review examines the patent literature on AKR1C3 inhibitors and suggests that although numerous potent inhibitors exist, further preclinical optimization is necessary before assessing their therapeutic potential in human diseases.

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community 2022->2026, 3.5 years Fin, no min, trans male

81 upvotes 2 months ago

A trans male shared his 3.5-year experience using finasteride for hair loss, noting improvements in hair density and hairline thickness without using minoxidil due to health concerns. He also uses Tołpa Torf shampoos and scalp serums, and emphasizes the importance of mental health and self-image in his journey.

community very happy with my results at 3 months of oral min + 4 months of fin

398 upvotes 8 months ago

The user is pleased with their hair growth results after using oral minoxidil (2.5mg) for 3 months and finasteride (1mg) for 4 months, despite experiencing significant shedding initially. They prefer oral treatments over topical due to convenience and concerns about toxicity to pets.

community 3.5 months on Minoxidil, Weekly 0.6mm microneedle

38 upvotes 6 months ago

A trans woman experiencing male pattern baldness has been using Minoxidil and microneedling for 3.5 months, noticing visible hair regrowth. Despite initial skepticism, progress is evident, though a hair transplant might be needed for fuller coverage.

community 34 MtF Hair progress timeline pics

38 upvotes 1 month ago

A 34-year-old MtF individual shared their hair regrowth journey using finasteride, minoxidil, estrogen, cyproterone acetate, and dutasteride, noting positive progress despite some setbacks. They experienced side effects like anxiety from cyproterone acetate and desired effects from estrogen, such as feminine fat distribution.

community After about 3 months of 2mg Estradiol (Sublingual) and 2.5mg Minox (Oral) daily

in Progress Pictures 160 upvotes 10 months ago

A person transitioning is using 2mg sublingual estradiol and 2.5mg oral minoxidil daily for hair regrowth, noting significant progress in three months. They plan to increase estrogen dosage and consider adding dutasteride, discussing the effects and challenges of transitioning.

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